Full length antigen priming enhances the CTL epitope-based DNA vaccine efficacy.

Pouriayevali MH; Bamdad T; Parsania M; Sari RD

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Full length antigen priming enhances the CTL epitope-based DNA vaccine efficacy.

机译：全长抗原引发增强了基于CTL表位的DNA疫苗的功效。

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Although CD8+ cytotoxic T lymphocyte (CTL) epitope-based DNA vaccination is valuable experience on vaccine research but many attempts are still continued to achieve acceptable protective response. To study the role of full length antigen in CTL epitope immunization, we evaluated cellular immunity of diverse patterns of complete Herpes simplex virus type 1 (HSV-1) glycoprotein B (gB) and the immunodominant CTL epitope (498-505) DNA injection in C57BL/6 mice. Optimal immune response was observed in the group immunized with the full length of gB in the first injection and CTL epitope in the second and third vaccination as assessed by lymphocyte proliferation assay (MTT), cytokine assay (ELISA) and CTL assay. B cell and spatially CD4+ T cell epitopes in full length protein might be important for appropriate priming of CTL immune response. These findings may have important implication for the improvement of CTL epitope based DNA vaccine against HSV and other pathogens.

机译：尽管基于CD8 +细胞毒性T淋巴细胞（CTL）表位的DNA疫苗接种是疫苗研究中的宝贵经验，但仍在继续进行许多努力来获得可接受的保护性反应。为了研究全长抗原在CTL表位免疫中的作用，我们评估了完整的单纯疱疹病毒1型（HSV-1）糖蛋白B（gB）和免疫显性CTL表位（498-505）DNA注射的多种模式的细胞免疫C57BL / 6小鼠。通过淋巴细胞增殖测定法（MTT），细胞因子测定法（ELISA）和CTL测定法评估，在第一次注射中用全长gB进行免疫的组中观察到最佳的免疫反应，在第二次和第三次接种中用CTL表位进行了免疫。全长蛋白质中的B细胞和空间CD4 + T细胞表位可能对CTL免疫应答的适当启动很重要。这些发现可能对改进基于CTL表位的针对HSV和其他病原体的DNA疫苗具有重要意义。

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《Cellular immunology》 |2011年第1期|共5页
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Pouriayevali MH; Bamdad T; Parsania M; Sari RD;
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中图分类细胞生物学;
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1. Full length antigen priming enhances the CTL epitope-based DNA vaccine efficacy. [J] . Pouriayevali MH, Bamdad T, Parsania M, Cellular immunology . 2011,第1期

机译：全长抗原引发增强了基于CTL表位的DNA疫苗的功效。
2. Co-immunisation with DNA encoding RANK/RANKL or 4-1BBL costimulatory molecules does not enhance effector or memory CTL responses afforded by immunisation with a tumour antigen-encoding DNA vaccine [J] . Herd KA, Wiethe C, Tindle RW Vaccine . 2007,第28期

机译：与编码RANK / RANKL或4-1BBL共刺激分子的DNA共同免疫不能增强由编码肿瘤抗原的DNA疫苗免疫所提供的效应子或记忆CTL反应
3. DNA vaccines encoding IL-2 linked to HPV-16 E7 antigen generate enhanced E7-specific CTL responses and antitumor activity. [J] . Lin CT, Tsai YC, He L, Immunology Letters . 2007,第2期

机译：编码与HPV-16 E7抗原连接的IL-2的DNA疫苗产生增强的E7特异性CTL反应和抗肿瘤活性。
4. Identification and optimization of HIV-specific CTL antigens for vaccine design [C] . Cesar Boggiano, Clemencia Pinilla, Bruce D.Walker, the International Peptide Symposium . 2001

机译：疫苗设计鉴定及优化HIV特异性CTL抗原
5. The development of DNA vaccines containing genes expressing specific enterotoxigenic Escherichia coli antigens and cytokines for the enhancement of antibody production. [D] . Cho, Suk Hyeon. 2003

机译：DNA疫苗的开发，该疫苗含有表达特异性产肠毒素的大肠杆菌抗原和细胞因子的基因，以增强抗体的产生。
6. Amiloride Enhances Antigen Specific CTL by Faciliting HBV DNA Vaccine Entry into Cells [O] . Shuang Geng, Yiwei Zhong, Shuang Wang, 2009

机译：阿米洛利通过促进HBV DNA疫苗进入细胞增强抗原特异性CTL
7. Endoplasmic reticulum targeting sequence enhances HBV-specific cytotoxic T lymphocytes induced by a CTL epitope-based DNA vaccine [O] . Xu Wei, Chu Yiwei, Zhang Ruihua, 2005

机译：内质网靶向序列增强基于CTL表位的DNA疫苗诱导的HBV特异性细胞毒性T淋巴细胞

Full length antigen priming enhances the CTL epitope-based DNA vaccine efficacy.

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