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首页> 外文期刊>Cellular immunology >Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansion.
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Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansion.

机译：黑色素瘤诱导的肿瘤抗原特异性T细胞扩增的抑制作用与总体T细胞扩增的抑制作用相当。

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We have observed that in vivo interaction between melanoma and resting T cells promotes suppression of antigen-driven proliferative T cell expansion. We hypothesized that this suppression would affect tumor antigen-specific T cell populations more potently than tumor-unrelated T cell populations. A B16F10 cell line was stably transfected to express low levels of the lymphocytic choriomeningitis virus (LCMV) glycoprotein GP33 (B16GP33). Mice bearing B16F10 or B16GP33 tumors were infected with LCMV, and proliferative expansion of LCMV epitope-specific T cell populations was quantified. In vitro and in vivo assays confirmed low levels of antigenic GP33 expression by B16GP33 tumors. Suppressed expansion of GP33-specific T cells was equivalent between mice bearing B16F10 and B16GP33 tumors. These observations suggest that the ability of growing melanoma tumors to impair antigen-driven proliferative expansion of activated T cells is global and not antigen-specific, and provide further insight into the influence of cancer on activated T cell homeostasis.
机译：我们已经观察到黑色素瘤和静止的T细胞之间的体内相互作用促进抑制抗原驱动的增殖性T细胞扩增。我们假设这种抑制作用将比与肿瘤无关的T细胞群体更有效地影响肿瘤抗原特异性T细胞群体。稳定转染B16F10细胞系以表达低水平的淋巴细胞脉络膜脑膜炎病毒（LCMV）糖蛋白GP33（B16GP33）。用LCMV感染携带B16F10或B16GP33肿瘤的小鼠，并定量LCMV表位特异性T细胞群的增殖性扩增。体外和体内试验证实B16GP33肿瘤抗原GP33表达水平较低。在携带B16F10和B16GP33肿瘤的小鼠之间，GP33特异性T细胞的抑制扩增相当。这些观察结果表明，生长中的黑素瘤肿瘤损害抗原驱动的活化T细胞增殖性扩展的能力是全局的，而不是抗原特异性的，并且提供了进一步的洞察力，了解癌症对活化T细胞稳态的影响。

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