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The monocyte-macrophage axis in the intestine

机译:肠道中的单核巨噬细胞轴

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摘要

Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew. (C) 2014 The Authors. Published by Elsevier Inc.
机译:巨噬细胞是肠粘膜中最丰富的白细胞之一,它们是维持体内稳态所必需的。但是,它们也与诸如炎症性肠病(IBD)等疾病的发病机制有关,为新型疗法提供了潜在的靶标。在这里,我们讨论了稳态过程中肠道单核细胞和巨噬细胞的功能,并描述了这些种群及其功能在感染和炎症过程中如何变化。此外,我们审查了当前的证据,即肠道巨噬细胞池需要循环血液单核细胞不断更新,这与大多数其他组织巨噬细胞似乎源于随后进行自我更新的原始前体不同。 (C)2014作者。由Elsevier Inc.发布

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