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首页> 外文期刊>Cellular immunology >Increased per cell IFN-gamma productivity indicates recent in vivo activation of T cells.
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Increased per cell IFN-gamma productivity indicates recent in vivo activation of T cells.

机译：每细胞IFN-γ生产率的提高表明最近体内T细胞活化。

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摘要

Immunization with vaccinia virus causes long-term immunity. Efforts have been made to characterize the T cells responsible for this protection. Recently, T cell subsets were described that not only co-express multiple cytokines, but also show increased per cell cytokine productivity. These highly productive cells are often considered to be the most protective. We used ELISPOT assays to measure per cell IFN-gamma productivity of vaccinia-specific T cells in childhood immunized adults immediately before and at different time points after vaccinia re-vaccination. Apart from an increase in frequency, we found a marked increase of IFN-gamma productivity following vaccinia re-vaccination. However, these changes were short-lived as both parameters quickly returned to baseline values within 22days after re-vaccination. Therefore, increased per cell IFN-gamma productivity seems to be a sign of recent in vivo T cell activation rather than a stable marker of a distinct T cell subset responsible for long-term immune protection.
机译：痘苗病毒的免疫引起长期免疫。已经做出努力来表征负责这种保护的T细胞。最近，描述了不仅共表达多种细胞因子，而且还显示出每细胞细胞因子生产率提高的T细胞亚群。这些高产细胞通常被认为是最具保护性的。我们使用ELISPOT分析法，在接种疫苗后和接种疫苗后的不同时间点，分别测量了儿童免疫成人中牛痘特异性T细胞的每细胞IFN-γ生产率。除了频率增加外，我们还发现在牛痘重新接种后，IFN-γ生产力显着增加。然而，这些变化是短暂的，因为两个参数在重新接种后的22天内迅速恢复到基线值。因此，每细胞IFN-γ生产率的提高似乎是近期体内T细胞活化的标志，而不是负责长期免疫保护的独特T细胞亚群的稳定标记。

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