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首页> 外文期刊>Cellular immunology >Relationship between CD107a expression and cytotoxic activity.
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Relationship between CD107a expression and cytotoxic activity.

机译：CD107a表达与细胞毒活性之间的关系。

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摘要

NK cells play important roles in innate immunity against tumors and infections of the host. Studies show that CD107a (LAMP-1) may be a marker for degranulation of NK and activated CD8+ T cells. In our study, the relationship between the expression of CD107a, cytokine secretion and cytotoxic activity in CD56+ NK, CD8+ T cells and lymphocytes has been determined after various stimuli. Effector cells from PBMCs of healthy subjects were isolated and K562 cell line was used as target of cytotoxicity. IL-2 stimulation resulted in a significant increase of CD107a expression in CD56+ NK, CD8+ T cells and lymphocytes. Increased expression of CD107a after IL-2 stimulation of NK cells was parallel to the increase of cytotoxicity. Our results suggest that CD107a expression may be a sensitive marker for the cytotoxic activity determination.
机译：NK细胞在抵抗肿瘤和宿主感染的先天免疫中起重要作用。研究表明，CD107a（LAMP-1）可能是NK和活化CD8 + T细胞脱粒的标志物。在我们的研究中，已通过各种刺激确定了CD107a的表达，CD56 + NK，CD8 + T细胞和淋巴细胞中细胞因子分泌与细胞毒性活性之间的关系。分离健康受试者的PBMC的效应细胞，并将K562细胞系用作细胞毒性的靶标。 IL-2刺激导致CD56 + NK，CD8 + T细胞和淋巴细胞中CD107a表达的显着增加。 IL-2刺激NK细胞后CD107a的表达增加与细胞毒性的增加平行。我们的结果表明，CD107a表达可能是确定细胞毒性活性的敏感标志。

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