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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function
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Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function

机译：预先暴露于低剂量适应辐射对具有不同Trp53功能的胎鼠的辐射诱导的致畸作用的影响

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Teratogenesis in tails and limb digits of fetal mice with varying Trp53 status was examined after exposure of pregnant females to 4 Gy gamma radiation with and without a prior 30-cGy exposure. Prior low-dose exposure modified the teratogenic effects of radiation in a manner dependent upon Trp53 status and gestation time. A 4-Gy exposure on gestation day 11 resulted in tail shortening and digit abnormalities. A 30-cGy exposure 24 h prior to a 4-Gy radiation exposure on day 11 reduced the extent of both digit abnormalities and the tail-shortening effects in Trp53(+/+) fetuses and also reduced tail shortening in Trp53(+/-) fetuses, but to a lesser extent. However, the pre-exposure enhanced the tail-shortening effects of 4 Gy in Trp53(-/-) fetuses. In contrast, a 30-cGy exposure given 24 h prior to a 4-Gy exposure on gestation day 12 had no effect on the reduced tail length resulting from the 4-Gy exposure of Trp53(+/+) or Trp53(+/-) fetuses, but it partly protected Trp53(-/-) fetuses against reduced tail length. A 4-Gy exposure alone on day 12 did not result in any increase in the frequency of digit abnormalities in Trp53(-/-) fetuses so any protective effect of the preirradiation could not be detected. However, the preirradiation did result in protection against in digit abnormalities in Trp53(+/-) fetuses. We conclude that radiation-induced teratogenesis reflects both Trp53-dependent and independent processes that lead to apoptosis, and these respond differently to prior adapting doses. (C) 2002 by Radiation Research Society. [References: 13]
机译：在怀孕的雌性暴露于4 Gyγ射线（有或没有事先暴露于30 cGy的情况下）后，检查了具有不同Trp53状态的胎鼠尾巴和四肢手指的致畸作用。先前的低剂量暴露以依赖于Trp53状态和妊娠时间的方式改变了辐射的致畸作用。在妊娠第11天暴露于4Gy会导致尾巴缩短和手指异常。在第11天接受4-Gy辐射之前24小时进行30-cGy暴露既减少了Trp53（+ / +）胎儿的数字异常程度和尾巴缩短效果，也减少了Trp53（+/-）的尾巴缩短）胎儿，但程度较小。但是，预暴露增强了Trp53（-/-）胎儿4 Gy的尾巴缩短作用。相反，在妊娠第12天进行4-Gy暴露之前24小时给予30-cGy暴露，对Trp53（+ / +）或Trp53（+/-）的4-Gy暴露导致的尾巴长度减少没有影响。 ）胎儿，但它部分保护Trp53（-/-）胎儿免受尾巴长度减少的伤害。仅在第12天进行4-Gy暴露不会导致Trp53（-/-）胎儿的指位异常发生率增加，因此无法检测到预照射的任何保护作用。但是，预辐照确实可以防止Trp53（+/-）胎儿出现手指异常。我们得出的结论是，辐射诱导的致畸作用反映了导致凋亡的Trp53依赖性和非依赖性过程，并且这些对先前适应剂量的反应不同。 （C）2002年，辐射研究学会。 [参考：13]

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