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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >Decreases in percentages of naive CD4 and CD8 T cells and increases in percentages of memory CD8 T-cell subsets in the peripheral blood lymphocyte populations of A-bomb survivors
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Decreases in percentages of naive CD4 and CD8 T cells and increases in percentages of memory CD8 T-cell subsets in the peripheral blood lymphocyte populations of A-bomb survivors

机译：原子弹幸存者外周血淋巴细胞群体中幼稚CD4和CD8 T细胞的百分比减少，记忆CD8 T细胞亚群的百分比增加

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Our previous studies have revealed a clear dose-dependent decrease in the percentage of naive CD4 T cells that are phenotypically CD45RA(+) in PBL among A-bomb survivors. However, whether there is a similar radiation effect on CD8 T cells has remained undetermined because of the unreliability of CD45 isoforms as markers of naive and memory subsets among the CD8 T-cell population. In the present study, we used double labeling with CD45RO and CD62L for reliable identification of naive and memory cell subsets in both CD4 and CD8 T-cell populations among 533 Hiroshima A-bomb survivors. Statistically significant dose-dependent decreases in the percentages of CD45RO(-)/CD62L(+) naive cells were found in the CD8 T-cell population as well as in the CD4 T-cell population. Furthermore, the percentages of CD45RO(+)/CD62L(+) and CD45RO(+)/CD62L(-) memory T cells were found to increase significantly with increasing radiation dose in the CD8 T-cell population but not in the CD4 T-cell population. These results suggest that the prior A-bomb exposure has induced long-lasting deficits in both naive CD4 and CD8 T-cell populations along with increased proportions of these particular subsets of the memory CD8 T-cell population. (C) 2004 by Radiation Research Society. [References: 48]
机译：我们以前的研究表明，A型炸弹幸存者中PBL的幼稚CD4 T细胞表型明显是CD45RA（+），其剂量明显降低。然而，由于CD45同工型作为CD8 T细胞群中幼稚和记忆子集的标志物的不可靠，尚不确定对CD8 T细胞是否有类似的放射作用。在本研究中，我们使用CD45RO和CD62L双重标记可靠地鉴定了533个广岛A型炸弹幸存者中CD4和CD8 T细胞群体中的幼稚和记忆细胞亚群。在CD8 T细胞群和CD4 T细胞群中发现CD45RO（-）/ CD62L（+）幼稚细胞百分比的统计学显着剂量依赖性降低。此外，发现CD45RO（+）/ CD62L（+）和CD45RO（+）/ CD62L（-）记忆T细胞的百分比随着放射剂量的增加而显着增加，而CD8 T细胞群体中却没有，细胞数量。这些结果表明，先前的原子弹暴露已引起幼稚的CD4和CD8 T细胞群体的长期缺陷，以及记忆CD8 T细胞群体的这些特定子集的比例增加。 （C）2004年，辐射研究学会。 [参考：48]

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