The effects of CD59 gene as a target gene on breast cancer cells.

Li B; Chu X; Gao M; Xu Y

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The effects of CD59 gene as a target gene on breast cancer cells.

机译：CD59基因作为靶基因对乳腺癌细胞的作用。

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The retroviral-vector-targeted CD59 gene (pSUPER-siCD59) was constructed and transfected into breast cells (MCF-7). The results demonstrated that the retroviral vector-mediated RNAi successfully suppressed human CD59 gene. The expression of CD59 decreased at both mRNA and protein levels. Knockdown of CD59 abrogated its protective effect on complement-mediated cytolysis. Fas and caspase-3 were remarkably upregulated, which induced apoptosis and tumor growth suppression in MCF-7 cells. In addition, overexpression of CD59 promoted the proliferation of MCF-7 cells and inhibited anti-apoptotic Bcl-2 expression. In conclusion, CD59 may be a promising target in the gene therapy of breast cancer.

机译：构建了逆转录病毒载体靶向的CD59基因（pSUPER-siCD59），并将其转染到乳腺细胞（MCF-7）中。结果表明，逆转录病毒载体介导的RNAi成功抑制了人CD59基因。 CD59的表达在mRNA和蛋白质水平均下降。击倒CD59取消了其对补体介导的细胞溶解的保护作用。 Fas和caspase-3明显上调，从而诱导MCF-7细胞凋亡和肿瘤生长抑制。另外，CD59的过表达促进MCF-7细胞的增殖并抑制抗凋亡Bcl-2表达。总之，CD59可能是乳腺癌基因治疗中有希望的靶标。

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《Cellular immunology》 |2011年第1期|共10页
作者
Li B; Chu X; Gao M; Xu Y;
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正文语种 eng
中图分类细胞生物学;
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1. The effects of CD59 gene as a target gene on breast cancer cells. [J] . Li B, Chu X, Gao M, Cellular immunology . 2011,第1期

机译：CD59基因作为靶基因对乳腺癌细胞的作用。
2. Identification of cytokine-induced nuclear factor-kappaB target genes in ovarian and breast cancer cells. [J] . Deregowski V, Delhalle S, Benoit V, Biochemical Pharmacology . 2002,第5a6期

机译：卵巢癌和乳腺癌细胞中细胞因子诱导的核因子-κB靶基因的鉴定。
3. SU11248, a selective tyrosine kinases inhibitor suppresses breast tumor angiogenesis and growth via targeting both tumor vasculature and breast cancer cells. [J] . Young E, Miele L, Tucker KB, Cancer biology & therapy . 2010,第7期

机译：SU11248是一种选择性酪氨酸激酶抑制剂，可同时靶向肿瘤血管和乳腺癌细胞，从而抑制乳腺癌的血管生成和生长。
4. Breast Cancer-specific Delivery of Therapeutic microRNA with Novel Breast Cancer-targeting Cell Penetrating Peptide-conjugated Gene Carrier [C] . Hwa Jeong Lee, Ran Namgung, Won Jong Kim, World biomaterials congress . 2012

机译：新型靶向乳腺癌的细胞穿透肽偶联基因载体与治疗性microRNA的乳腺癌特异性递送。
5. Development of an in vitro three-dimensional breast tissue model to decipher the effects of stromal heterogeneity on normal and cancerous mammary epithelial cells. [D] . McCave, Erin Jennifer. 2014

机译：体外三维乳腺组织模型的开发，以解释基质异质性对正常和癌性乳腺上皮细胞的影响。
6. Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: Evidence that they exert tumoricidal effects via tumor tropism [O] . BO-RIM YI, KELVIN J. CHOI, SEUNG U. KIM, -1

机译：表达选择性靶向人乳腺癌细胞的自杀基因的干细胞的治疗潜力：它们通过肿瘤嗜性发挥杀伤作用的证据
7. Identification of fibroblast growth factor-8b target genes associated with early and late cell cycle events in breast cancer cells. [O] . Nilsson, E M, Brokken, Leon, Narvi, E, 2012

机译：鉴定与乳腺癌细胞早期和晚期细胞周期事件相关的成纤维细胞生长因子-8b靶基因。
8. Developing a Novel Mouse Model for Breast Cancer by Targeting Oncogenes to Mammary Progenitor Cells. [R] . Li, Y. 2005

机译：通过将致癌基因靶向乳腺祖细胞开发新的乳腺癌小鼠模型。

The effects of CD59 gene as a target gene on breast cancer cells.

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