Rationalizing thymic selection for functional T-cells: A commentary

Cohn Melvin

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Rationalizing thymic selection for functional T-cells: A commentary

机译：合理化功能性T细胞的胸腺选择：评论

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What are the minimum specificity requirements of a thymic selective process that establishes (1) restrictive recognition of peptide, (2) the Self (S)-Nonself (NS) discrimination, and (3) the categories of effector function? Given an answer to that question, how well does it fit with the observed selective processes in thymus where T-cells are generated? Any discrepancies between the two must be rationalized. The goal of this essay is to attempt just that. (C) 2015 Elsevier Inc. All rights reserved.

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《Cellular immunology》 |2015年第2期|共5页
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Cohn Melvin;
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正文语种 eng
中图分类细胞生物学;
关键词
Thymic positive selection; Thymic negative selection; T-helpers; T-suppressors; Cytotoxic T-cells; Peripheralized T-cells;

机译：胸腺阳性选择;胸腺阴性选择;T辅助物;T抑制物;细胞毒性T细胞;外周T细胞;

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1. Rationalizing thymic selection for functional T-cells: A commentary [J] . Cohn Melvin Cellular immunology . 2015,第1a2期

机译：合理化功能性T细胞的胸腺选择：评论
2. Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. [J] . Thomas M Schmitt, David H Aggen, Ingunn M Stromnes, Blood: The Journal of the American Society of Hematology . 2013,第3期

机译：尽管超过胸腺选择的阈值，但肿瘤/自我抗原的增强亲和力鼠T细胞受体可以在基因治疗中是安全的。
3. Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene [J] . Yoshinaga Ito, Shimon Sakaguchi Arthritis Research . 2012,第Suppla1期

机译：由于ZAP-70基因突变导致胸腺T细胞选择改变而引起的自身免疫性关节炎
4. CURRENT STATUS OF THYMOSIN RESEARCH: EVIDENCE FOR THE EXISTENCE OF A FAMILY OF THYMIC FACTORS THAT CONTROL T-CELL MATURATION? [C] . Teresa L. K. Low, Gary B. Thurman, Carolina Chincarini, International Symposium on Thymosins in Health and Disease . 2012

机译：胸腺素研究的现状：控制T细胞成熟的胸腺系列系列的证据？
5. The function of thymic nurse cells and intra-TNC macrophages during T-cell development. [D] . Samms, Michael Desmond. 2003

机译：胸腺护士细胞和TNC内巨噬细胞在T细胞发育过程中的功能。
6. Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor T44 and T11): analysis of the functional relationship among different pathways of activation. [O] . A Moretta, A Poggi, D Olive, 1987

机译：缺乏参与T细胞活化的分子（T3 T细胞受体T44和T11）的T细胞变体的选择和表征：分析不同活化途径之间的功能关系。
7. Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor, T44, and T11): analysis of the functional relationship among different pathways of activation. [O] . Moretta, A, Poggi, A, Olive, D, 1987

机译：缺乏参与T细胞活化的分子（T3 T细胞受体，T44和T11）的T细胞变体的选择和表征：分析不同活化途径之间的功能关系。

Rationalizing thymic selection for functional T-cells: A commentary

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