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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >LOW-DOSE IONIZING RADIATION DECREASES THE FREQUENCY OF NEOPLASTIC TRANSFORMATION TO A LEVEL BELOW THE SPONTANEOUS RATE IN C3H 10T1/2 CELLS
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LOW-DOSE IONIZING RADIATION DECREASES THE FREQUENCY OF NEOPLASTIC TRANSFORMATION TO A LEVEL BELOW THE SPONTANEOUS RATE IN C3H 10T1/2 CELLS

机译：低剂量电离辐射使C3H 10T1 / 2细胞的自发转化率低于自发率

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We have previously shown that chronic exposure of plateau-phase C3H 10T1/2 cells to Co-60 gamma radiation at doses as low as 10 cGy protected the cells against neoplastic transformation by a subsequent large acute radiation exposure. We have also shown that this induced resistance to neoplastic transformation correlated with an increased ability to repair radiation-induced chromosome breaks. We now show that a single exposure of quiescent cells to doses as low as 0.1 cGy also reduces the risk of neoplastic transformation, from the spontaneous level to a rate three- to fourfold below that level. Higher doses, up to 10 cGy at the same dose rate (0.24 cGy/min), did not reduce the neoplastic transformation frequency further. This protective effect was seen only in irradiated cells that were allowed to incubate at 37 degrees C before release from contact inhibition. Cells released into low-density subcultures immediately after irradiation had unchanged neoplastic transformation frequencies. These results demonstrate that low or chronic exposure to radiation can induce processes which protect the cell against naturally occurring as well as radiation-induced alterations that lead to cell transformation. If similar processes are induced in human cells, the results also suggest that a single low dose, at background or occupational exposure levels, may in some circumstances reduce rather than increase cancer risk, a conclusion inconsistent with the linear no-threshold model of cancer risk from radiation. (C) 1996 by Radiation Research Society [References: 21]
机译：先前我们已经表明，高原期C3H 10T1 / 2细胞以低至10 cGy的剂量长期暴露于Co-60γ射线，可以保护细胞免于随后的大量急性放射线照射而发生肿瘤转化。我们还表明，这种对肿瘤转化的诱导抗性与修复辐射诱导的染色体断裂的能力增强相关。我们现在显示，静态细胞单次暴露至低至0.1 cGy的剂量也可降低肿瘤转化的风险，从自然水平降至低于该水平三至四倍的比率。在相同剂量率（0.24 cGy / min）下，最高剂量可达10 cGy，并没有进一步降低肿瘤转化的频率。仅在允许从接触抑制释放之前在37°C下孵育的辐照细胞中才能看到这种保护作用。辐射后立即释放到低密度亚培养物中的细胞具有不变的肿瘤转化频率。这些结果表明，低或长期暴露于辐射下可以诱导保护细胞免受自然发生的过程，以及辐射诱导的导致细胞转化的改变。如果在人体细胞中诱导相似的过程，则结果还表明，在背景或职业暴露水平下，单次低剂量可能在某些情况下降低而不是增加癌症风险，这一结论与癌症风险的线性无阈值模型不一致从辐射。 （C）1996年，由放射研究学会[参考文献：21]

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