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The locus of microRNA-10b: A critical target for breast cancer insurgence and dissemination

机译：microRNA-10b的基因座：乳腺癌暴动和传播的关键目标

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Contemporary microRNA research has led to significant advances in our understanding of the process of tumorigenesis. MicroRNAs participate in different events of a cancer cell's life, through their ability to target hundreds of putative transcripts involved in almost every cellular function, including cell cycle, apoptosis, and differentiation. The relevance of these small molecules is even more evident in light of the emerging linkage between their expression and both prognosis and clinical outcome of many types of human cancers. This identifies microRNAs as potential therapeutic modifiers of cancer phenotypes. From this perspective, we overview here the miR-10b locus and its involvement in cancer, focusing on its role in the establishment (miR-10b*) and spreading (miR-10b) of breast cancer. We conclude that targeting the locus of microRNA 10b holds great potential for cancer treatment.
机译：当代的microRNA研究已使我们对肿瘤发生过程的理解有了重大进展。 MicroRNA通过靶向几乎所有细胞功能（包括细胞周期，细胞凋亡和分化）涉及的数百种假定转录物的能力，参与了癌细胞生命的不同事件。鉴于这些小分子的表达与许多类型的人类癌症的预后和临床结果之间的联系日益紧密，这些小分子的相关性更加明显。这将microRNA鉴定为潜在的癌症表型治疗修饰剂。从这个角度出发，我们在这里概述miR-10b基因座及其在癌症中的参与，重点是它在乳腺癌的建立（miR-10b *）和扩散（miR-10b）中的作用。我们得出的结论是，靶向microRNA 10b的基因座在癌症治疗中具有巨大的潜力。

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