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首页> 外文期刊>Cell cycle >FBH1 protects melanocytes from transformation and is deregulated in melanomas
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FBH1 protects melanocytes from transformation and is deregulated in melanomas

机译：FBH1保护黑素细胞免于转化，并在黑素瘤中失控

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摘要

FBH1 is a member of the UvrD family of DNA helicases and plays a crucial role in the response to DNA replication stress. In particular, upon DNA replication stress, FBH1 promotes double-strand breakage and activation of the DNA-PK and ATM signaling cascades in a helicase-dependent manner. In the present manuscript, we show that FBH1 is often deleted or mutated in melanoma cells, which results in their increased survival in response to replicative stress. Accordingly, FBH1 depletion promotes UV-mediated transformation of human melanocytes. Thus, FBH1 inactivation appears to contribute to oncogenic transformation by allowing survival of cells undergoing replicative stress due to external factors such as UV irradiation.
机译：FBH1是DNA解旋酶UvrD家族的成员，在对DNA复制压​​力的反应中起着至关重要的作用。特别地，在DNA复制压​​力下，FBH1以解旋酶依赖性方式促进双链断裂以及DNA-PK和ATM信号级联的激活。在本手稿中，我们显示FBH1在黑素瘤细胞中经常被删除或突变，这导致它们在复制压力下的存活率提高。因此，FBH1消耗促进紫外线介导的人类黑素细胞转化。因此，FBH1失活似乎通过允许由于诸如紫外线照射等外部因素而遭受复制应激的细胞存活，从而促进了致癌转化。

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