...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Counteracting stem cell expansion during wound repair Distinct roles of non-canonical Wnt and TGF-??
【24h】

Counteracting stem cell expansion during wound repair Distinct roles of non-canonical Wnt and TGF-??

机译：在伤口修复过程中抵消干细胞的扩增非经典Wnt和TGF-β的独特作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To repair extensive areas of tissue loss, a common strategy for many adult organisms is to re-awaken long dormant developmental pathways in order to reconstitute the complete structure of original tissues de novo. Zebrafish and amphibian tissue regeneration requires the formation of a mesenchymal progenitor mass (termed "blastema") that possesses spatial cues to direct tissue reorganization.1 In most mammals, de novo tissue regeneration is typically limited to replacement of specific units, such as hair follicles2 and intestinal crypts.3 For this to occur, the proper spatial distribution of epithelial stem and differentiated cells must be re-established. To replace epithelial structures, stem cells must first expand into the wound. Next, stem cells must then become distributed into a developing niche that supports cellular differentiation. These epithelial cell behaviors typically require cues from multiple mesenchymal cell types that modulate developmental pathways, including Wnt and TGF-beta/BMP pathways. An important goal is to identify such mesenchymal cell types and their function in repair.
机译：为了修复广泛的组织损失区域，许多成年生物的普遍策略是重新唤醒长期休眠的发育途径，以重新构建原始组织的完整结构。斑马鱼和两栖动物的组织再生需要形成具有空间线索的间充质祖细胞（称为“胚母细胞”），以指导组织重组。1在大多数哺乳动物中，从头组织再生通常仅限于替换特定单位，例如毛囊2为了做到这一点，必须重新建立上皮干细胞和分化细胞的适当空间分布。要替换上皮结构，干细胞必须首先扩展到伤口中。接下来，干细胞必须随后分布到支持细胞分化的发育中。这些上皮细胞的行为通常需要来自多种间充质细胞类型的信号，这些信号可调节发育途径，包括Wnt和TGF-β/ BMP途径。一个重要的目标是确定这种间充质细胞类型及其修复功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号