From mice to human: the 'two-hit model' of leukemogenesis.

Kosmider O; Moreau-Gachelin F

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From mice to human: the 'two-hit model' of leukemogenesis.

机译：从小鼠到人类：白血病发生的“两次打击模型”。

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The Friend virus-infected mice as well as the Spi-l/PU.transgenic mice develop acute erythroleukemia that evolve as multi-step processes, recapitulating many features of die acute myeloid leukemia (AML) in humans. These animal models demonstrate that one mutation interfering with differentiation and one mutation conferring a prohferative advantage to cells cause an acute leukemia.

机译：被Friend病毒感染的小鼠以及Spi-1 / PU。转基因小鼠发展成急性红白血病，该红白血病以多步过程演变，从而概括了人类急性髓性白血病（AML）的许多特征。这些动物模型证明一种干扰分化的突变和一种赋予细胞增殖优势的突变会引起急性白血病。

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《Cell cycle》 |2006年第6期|共2页
作者
Kosmider O; Moreau-Gachelin F;
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正文语种 eng
中图分类细胞生物学;
关键词
Cell Transformation; Neoplastic; Friend murine leukemia virus; Leukemia; Erythroblastic; Acute; 细胞转化; 肿瘤; 白血病; 幼红细胞; 急性; 白血病; 粒细胞; 急性;

机译：Cell Transformation;Neoplastic;Friend murine leukemia virus;Leukemia;Erythroblastic;Acute;细胞转化;肿瘤;白血病;幼红细胞;急性;白血病;粒细胞;急性;

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1. From mice to human: the "two-hit model" of leukemogenesis. [J] . Kosmider O, Moreau-Gachelin F Cell cycle . 2006,第6期

机译：从小鼠到人类：白血病发生的“两次打击模型”。
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5. Modeling human immunodeficiency virus-1 (HIV-1) infection in the male reproductive tract (MRT) using humanized mice [D] . Fisher, Suhrim. 2016

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6. Mice survival in a two-hit model of sepsis depends on intratracheal P. aeruginosa bacterial load [O] . D Restagno, J-M Bonnet, A Kodjo, 2014

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7. From Mice to Human: The “Two-Hit Model” of Leukemogenesis [O] . Olivier Kosmider, Françoise Moreau-Gachelin 2006

机译：从小鼠到人类：白血病的“双重模型”

From mice to human: the 'two-hit model' of leukemogenesis.

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