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首页> 外文期刊>Cell cycle >Dormancy of solitary metastatic cells.
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Dormancy of solitary metastatic cells.

机译：孤立转移细胞的休眠。

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After arriving in a secondary site metastatic cells may begin proliferating, undergo apoptosis or remain as solitary dormant cells. The process of metastasis, although dangerous, is extremely inefficient with the majority of the cells undergoing apoptosis and thus becoming clinically irrelevant. Of the cells that begin proliferating, the few that make it past the micrometastasis stage may be of immediate clinical relevance. Dormant cells, while not of immediate clinical concern, are believed to be at least in part responsible for cancer recurrence that can occur decades after apparently successful initial treatment. Dormant solitary cells are different from "dormant" micrometastases, in which active proliferation is balanced by apoptosis. The mechanisms of cell cycle regulation and the function of the molecules regulating this process are well understood. However, there is relatively little known about the mechanisms controlling cell cycle regulation and dormancy of solitary metastatic cells. There areseveral inherent difficulties impeding the study of solitary cells. This review paper will examine the models used in the study of dormant solitary metastatic cells, methods of imaging and studying these cells, the molecular mechanisms believed to be responsible for solitary cell dormancy, and finally the unique treatment challenges posed by these cells.
机译：到达次要部位后，转移性细胞可能开始增殖，发生凋亡或保持为单独的休眠细胞。转移的过程虽然很危险，但由于大多数细胞都发生凋亡，因此转移效率极其低下，因此与临床无关。在开始增殖的细胞中，少数进入微转移阶段的细胞可能具有直接的临床意义。休眠细胞虽然没有立即引起临床关注，但被认为至少部分负责可能在明显成功的初始治疗后数十年发生的癌症复发。休眠的孤立细胞与“休眠”的微转移不同，后者的活动性增殖通过细胞凋亡来平衡。细胞周期调节的机制和调节该过程的分子功能是众所周知的。然而，关于控制细胞周期调节和孤立转移细胞休眠的机制知之甚少。有许多固有的困难阻碍了单细胞的研究。这篇综述文章将研究用于研究休眠的孤立转移细胞的模型，成像和研究这些细胞的方法，被认为是导致孤立细胞休眠的分子机制，以及这些细胞所带来的独特治疗挑战。

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