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首页> 外文期刊>Cell cycle >Nurse cell of Trichinella spp. as a model of long-term cell cycle arrest.
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Nurse cell of Trichinella spp. as a model of long-term cell cycle arrest.

机译：旋毛虫属的护士细胞。作为长期细胞周期停滞的模型。

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摘要

Nurse cell (NC), formed from skeletal muscle cells upon infection with parasitic nematode trichina, presents a rare system of long-term suspension in the cell cycle. Signaling pathways and general biological functions of Trichinella spiralis NC, inferred from network analysis of competitive expression microarray data (NC vs. C2C12 myoblasts and myotubes), performed in Ingenuity Pathways Analysis (IPA) software and confirmed by Real-Time PCR, are presented. Assuming 4N DNA content in NC nuclei, its cell cycle arrest is identified herein as a hypermitogenic of G(1)-like type, accompanied by induction of senescence, underpinned by increased expression of p15, p16 and p57 cell cycle inhibitors, as well as overexpression of senescence-associated, beta-galactosidase and numerous secretory factors. Growth factor signaling, with predominant role of EGF, cytokine signaling and G-protein-coupled receptor signaling, are suggested as dominant NC signal transduction pathways. Fos, FosB, STAT6, CREBL2, ID4 and retinoic acid dependent nuclear receptors appear to be the main factors determining NC specific gene transcription. Antigen presentation, complement signaling and beta-amyloid processing pathways are also identified as operating in NC. In general, NC pathology is found to pertain to cancer, as well as other, including immunological and neurological, disorders.
机译：寄生虫线虫感染后，由骨骼肌细胞形成的护士细胞（NC）在细胞周期中提供了罕见的长期悬浮系统。介绍了通过竞争性表达微阵列数据（NC与C2C12成肌细胞和成肌细胞）的网络分析推断出的旋毛虫NC的信号传导途径和一般生物学功能，这些反应是在Ingenuity Pathways Analysis（IPA）软件中进行并经实时PCR证实的。假设NC核中的4N DNA含量，其细胞周期停滞在本文中被鉴定为G（1）型类型的高丝裂原，伴随着衰老的诱导，并以p15，p16和p57细胞周期抑制剂的表达增加为基础衰老相关的β-半乳糖苷酶和许多分泌因子的过度表达。建议以生长因子信号传导，EGF，细胞因子信号传导和G蛋白偶联受体信号传导为主，作为主要的NC信号转导途径。 Fos，FosB，STAT6，CREBL2，ID4和视黄酸依赖性核受体似乎是决定NC特定基因转录的主要因素。抗原呈递，补体信号传导和β-淀粉样蛋白加工途径也被确定为在NC中起作用。通常，发现NC病理学与癌症以及其他疾病有关，包括免疫学和神经学疾病。

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