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Tumor vaccines in 2010: need for integration.

机译:2010年的肿瘤疫苗:需要整合。

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摘要

Induction of tumor-specific immunity is an attractive approach to cancer therapy, however to date every major pivotal trial has resulted in failure. While the phenomena of tumor-mediated immune suppression has been known for decades, only recently have specific molecular pathways been elucidated, and for the first time, rationale means of intervening and observing results of intervention have been developed. In this review we describe major advances in our understanding of tumor escape from immunological pressure and provide some possible therapeutic scenarios for enhancement of efficacy in future cancer vaccine trials.
机译:诱导肿瘤特异性免疫是癌症治​​疗的一种有吸引力的方法,但是迄今为止,每个主要的关键试验都导致失败。尽管肿瘤介导的免疫抑制现象已经知道了数十年,但直到最近才阐明了特定的分子途径,并且首次开发了干预和观察干预结果的基本手段。在这篇综述中,我们描述了我们对免疫压力导致的肿瘤逃逸的理解的主要进展,并提供了一些可能的治疗方案,以增强未来癌症疫苗试验的功效。

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