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首页> 外文期刊>Cellular immunology >Double stranded RNA- relative to other TLR ligand-activated dendritic cells induce extremely polarized human Th1 responses.
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Double stranded RNA- relative to other TLR ligand-activated dendritic cells induce extremely polarized human Th1 responses.

机译：相对于其他TLR配体激活的树突状细胞，双链RNA诱导极极化的人类Th1反应。

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摘要

To better understand the relative efficiencies of using different TLR ligand-activated DCs to induce human CD4(+) T lymphocyte responses, human DCs were activated with two viral and two bacterial TLR ligands, and their production of IL12, TNFalpha, and IL10 was examined. While the two viral TLR ligands (ssRNA and dsRNA) induced DC production of detectable levels of IL12p70, DCs activated by the two bacterial TLR ligands (LPS and flagellin) induced increased proliferation of human allogeneic naive CD4(+) T cells. dsRNA-activated DCs induced increased Th1 and decreased Th2 differentiation, resulting in extremely polarized responses relative to those induced by unstimulated and other TLR ligand-activated DCs. Neutralization of IL12p70 abrogated most of the Th1 skewing induced by all TLR ligand-activated moDCs. Collectively, these results demonstrate that dsRNA-activated DCs induce more highly polarized human Th1 responses than the other TLR ligand-activated DCs tested here. These results have implications for TLR ligands in immunotherapy.
机译：为了更好地了解使用不同的TLR配体激活的DC诱导人CD4（+）T淋巴细胞反应的相对效率，人类DC被两个病毒和两个细菌TLR配体激活，并检查了它们的IL12，TNFα和IL10产生。虽然两个病毒TLR配体（ssRNA和dsRNA）诱导DC产生可检测水平的IL12p70，但由两个细菌TLR配体（LPS和鞭毛蛋白）激活的DC诱导人类同种异体幼稚CD4（+）T细胞增殖增加。 dsRNA激活的DC诱导Th1分化增加，Th2分化降低，相对于未受刺激的TLR和其他TLR配体激活的DC诱导的分化，导致极极化的响应。 IL12p70的中和消除了所有TLR配体激活的moDC诱导的大部分Th1偏斜。总的来说，这些结果表明，与此处测试的其他TLR配体激活的DC相比，dsRNA激活的DC诱导更高极化的人类Th1反应。这些结果对免疫疗法中的TLR配体具有影响。

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