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首页> 外文期刊>Cellular immunology >Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis.
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Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis.

机译：1型糖尿病和多发性硬化症患者CD8 + CD28-T抑制淋巴细胞的数量缺陷。

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摘要

Type 1 diabetes mellitus (T1D) and multiple sclerosis (MS) are organ-specific autoimmune diseases leading to an attack of auto-aggressive lymphocytes against the pancreatic beta-cells and central nervous system, respectively. Using four-colour flow cytometry, T-lymphocyte populations having an important function in autoimmune processes were analyzed. T-regulatory cells (Treg) CD4(+)CD25(+)CD127(low), T-suppressor cells (Ts) CD8(+)CD28(-), activated helper CD4(+)CD25(+)CD127(+) and cytotoxic CD8(+)CD25(+) T-cells and also naive CD4(+)CD45RA(+) and memory T-cells CD4(+)CD45RO(+) were compared in the group of patients with T1D (n=30), MS (n=31) and in the group of healthy controls (n=29). Significant differences in Ts cells, activated helper and cytotoxic cells and also memory T-cells were recognized in the group of T1D patients compared to healthy controls. Ts population was significantly lowered in MS patients as well. However, no significant differences were noticed in Treg population. The observed data demonstrate significant differences among patients with T1D and MS in comparison to healthy individuals.
机译：1型糖尿病（T1D）和多发性硬化症（MS）是器官特异性自身免疫性疾病，分别导致自发性攻击淋巴细胞攻击胰腺β细胞和中枢神经系统。使用四色流式细胞仪，分析了在自身免疫过程中具有重要功能的T淋巴细胞群体。 T调节细胞（Treg）CD4（+）CD25（+）CD127（低），T抑制细胞（Ts）CD8（+）CD28（-），激活的辅助CD4（+）CD25（+）CD127（+）在患有T1D的患者组中比较了细胞毒性CD8（+）CD25（+）T细胞，幼稚CD4（+）CD45RA（+）和记忆T细胞CD4（+）CD45RO（+）（n = 30） ），MS（n = 31）和健康对照组（n = 29）。与健康对照组相比，在T1D患者组中认识到Ts细胞，活化的辅助细胞和细胞毒性细胞以及记忆T细胞有显着差异。 MS患者的Ts人群也显着降低。然而，在Treg人群中没有发现显着差异。观察到的数据表明，与健康个体相比，T1D和MS患者之间存在显着差异。

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