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首页> 外文期刊>Cell and Tissue Research >Gas1 is present in germinal niches of developing dentate gyrus and cortex
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Gas1 is present in germinal niches of developing dentate gyrus and cortex

机译：Gas1存在于发育中的齿状回和皮层的生发壁ni中

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摘要

Gas1 is a pleiotropic protein that inhibits cell growth when overexpressed in tumors but during development, it acts as a co-receptor for sonic hedgehog to promote the proliferation and survival of various growing organs and systems. This protein has been extensively studied during development in the cerebellum. However, in other structures of the central nervous system, information concerning Gas1 is limited to in situ hybridization studies. We investigate the pattern of Gas1 expression during various developmental stages of the cortex and dentate gyrus of the mouse brain. The levels of Gas1 decrease in the developing brain and the protein is mainly found in progenitor cells during the development of the cortex and dentate gyrus.
机译：Gas1是一种多效性蛋白，在肿瘤中过表达时会抑制细胞生长，但在发育过程中，它作为声波刺猬的共同受体来促进各种生长器官和系统的增殖和存活。在小脑发育过程中已对该蛋白质进行了广泛研究。但是，在中枢神经系统的其他结构中，有关Gas1的信息仅限于原位杂交研究。我们调查的Gas1表达模式在小鼠大脑皮层和齿状回的各个发育阶段。 Gas1的水平在发育中的大脑中减少，并且该蛋白主要在皮质和齿状回的发育过程中的祖细胞中发现。

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