• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >MANGANESE CHLORIDE TREATMENT DOES NOT PROTECT AGAINST ACUTE RADIATION INJURY OF SKIN OR CRYPT CELLS
【24h】

MANGANESE CHLORIDE TREATMENT DOES NOT PROTECT AGAINST ACUTE RADIATION INJURY OF SKIN OR CRYPT CELLS

机译：氯化锰处理不能防止皮肤或隐窝细胞受到急性放射伤害

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Metallothionein (MT), the synthesis of which can be induced by metalloelement administration, is a known radical scavenger. This study investigated the possible protective effect of MT against acute radiation injury. Manganese chloride (10 mg of manganese/kg) was administered intraperitoneally to male C3H/He mice 24 h prior to irradiation. The paw of each mouse was irradiated locally, and the acute skin reaction was scored daily and averaged, Acute radiation injury of the small intestine was studied using an LD(50/8) assay and a gut microcolony assay after abdominal irradiation, An LD(50/8) value represents the radiation dose required to kill 50% of animals within 8 days. The number of microcolonies per tissue section was counted 3.5 days after irradiation. The level of MT in the liver, skin and intestine was determined by a modified Hg-203-binding assay. Acute skin reaction was not prevented by manganese pre-administration. The LD(50/8) values of manganese-pretreated and control mice were 19.4 and 18.4 Gy, respectively, However, the difference was not significant. The number of microcolonies was not significantly different for these two groups in the dose range of 13-19 Gy. The level of MT in the skin and intestine was not increased by administration of manganese, although a sixfold increase was observed in the liver, In conclusion, manganese chloride treatment of mice 24 h prior to irradiation did not significantly protect skin and small intestine against acute radiation injury, because such a treatment did not result in increased levels of MT in the skin and small intestine. (C) 1995 by Radiation Research Society [References: 20]
机译：金属硫蛋白（MT）是已知的自由基清除剂，其合成可以通过金属元素的施用诱导。这项研究调查了MT对急性放射损伤的可能的保护作用。辐照前24小时向雄性C3H / He小鼠腹膜内给予氯化锰（10毫克锰/千克）。局部照射每只小鼠的脚掌，每天对急性皮肤反应进行评分并取平均值，腹部照射后，采用LD（50/8）测定法和肠道微菌落测定法研究小肠的急性放射损伤，LD（ 50/8）值表示在8天内杀死50％的动物所需的辐射剂量。照射后3.5天计数每个组织切片的微菌落数。肝，皮肤和肠道中MT的水平通过改良的Hg-203结合测定法确定。锰的预先给药不能预防急性皮肤反应。锰预处理小鼠和对照组小鼠的LD（50/8）值分别为19.4 Gy和18.4 Gy，但是差异不显着。在13-19 Gy的剂量范围内，这两组的小菌落数量没有显着差异。虽然在肝脏中观察到六倍的锰水平，但是施用锰后皮肤和肠中MT的水平并未增加。总而言之，辐照前24小时用氯化锰处理小鼠并不能显着保护皮肤和小肠免于急性辐射损伤，因为这样的治疗并未导致皮肤和小肠中MT水平的升高。 （C）1995年，放射研究学会[参考：20]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号