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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >RELATIVE BIOLOGICAL EFFECTIVENESS OF TRITIUM FOR INDUCTION OF MYELOID LEUKEMIA IN CBA/H MICE
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RELATIVE BIOLOGICAL EFFECTIVENESS OF TRITIUM FOR INDUCTION OF MYELOID LEUKEMIA IN CBA/H MICE

机译：RIT在CBA / H小鼠中诱导髓样白血病的相对生物学效应

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摘要

To help resolve uncertainties as to the most appropriate weighting factor for tritium beta rays, a large experiment was carried out to measure the relative biological effectiveness (RBE) of tritiated water compared to X rays for the induction of myeloid leukemia in male mice of the CBA/H strain. The study was designed to estimate the lifetime incidence of myeloid leukemia in seven groups of about 750 mice each; radiation exposures were approximately 0, 1, 2 and 3 Gy both for tritiated water and for X rays. The lifetime incidence of leukemia in these mice increased from 0.13% in the control group to 6-8% in groups exposed to higher radiation doses. The results were fitted to various equations relating leukemia incidence to radiation dose, using both the raw data and data corrected for cumulative mouse-days at risk. The calculated RBE values for tritium beta rays compared to X rays ranged from 1.0 +/- 0.5 to 1.3 +/- 0.3. A best estimate of the RBE for this experiment was about 1.2 +/- 0.3. A w(R) value of 1 would thus appear to be more appropriate than a w(R) Of 2 for tritium beta rays. (C) 1995 by Radiation Research Society [References: 31]
机译：为帮助解决关于beta射线最合适的加权因子的不确定性，进行了一项大型实验，以测量tri化水与X射线相比在CBA雄性小鼠中诱发髓样白血病的相对生物学有效性（RBE） / H应变。这项研究旨在评估7组每只约750只小鼠的髓样白血病的终生发生率。 tri化水和X射线的辐射暴露分别约为0、1、2和3 Gy。这些小鼠的终生白血病发病率从对照组的0.13％增加到暴露于较高辐射剂量的组的6-8％。使用原始数据和针对有风险的累积小鼠日数校正的数据，将结果拟合到将白血病发生率与辐射剂量相关的各种方程式。与X射线相比，triβ射线的计算RBE值范围为1.0 +/- 0.5至1.3 +/- 0.3。对于该实验，RBE的最佳估计约为1.2 +/- 0.3。因此，对于beta射线，w（R）值为1似乎比2的w（R）更合适。 （C）1995年，辐射研究学会[参考文献：31]

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