Oncogenic tyrosine kinases, DNA repair and survival: the role of Bcl-xL deamidation in transformation and genotoxic therapies.

Alexander DR

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Oncogenic tyrosine kinases, DNA repair and survival: the role of Bcl-xL deamidation in transformation and genotoxic therapies.

机译：致癌酪氨酸激酶，DNA修复和存活：Bcl-xL脱酰胺作用在转化和基因毒性治疗中的作用。

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Dysfunctional tyrosine kinases comprise an important class of oncogenes. We have generated a mouse model in which an oncogenic tyrosine kinase (OTK) causes T-lineage tumors. The model facilitates investigation of early oncogenic events in pretumorigenic thymocytes. The OTK transforms thymocytes by a 'double whammy' mechanism whereby on the one hand it inhibits DNA repair, leading to genomic instability, and on the other blocks DNA damage-induced apoptosis. The OTK-mediated blockade of apoptosis involves inhibition of DNA-damage triggered Bcl-xL deamidation, thereby preserving the protein's pro-survival functions. The pharmaceutical promotion of Bcl-xL deamidation might render cancer cells more sensitive to genotoxic attack.

机译：功能异常的酪氨酸激酶包括一类重要的癌基因。我们已经生成了一种小鼠模型，其中致癌酪氨酸激酶（OTK）引起T系肿瘤。该模型有助于调查致瘤前胸腺细胞中的早期致癌事件。 OTK通过“双重打击”机制转化胸腺细胞，从而一方面抑制DNA修复，导致基因组不稳定，另一方面阻止DNA损伤诱导的细胞凋亡。 OTK介导的凋亡阻滞涉及抑制DNA损伤触发的Bcl-xL脱酰胺作用，从而保留了该蛋白的促存活功能。 Bcl-xL脱酰胺作用的药物促进可能会使癌细胞对遗传毒性攻击更加敏感。

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《Cell cycle》 |2004年第5期|共4页
作者
Alexander DR;
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正文语种 eng
中图分类细胞生物学;
关键词
amidation/deamidation; Protein-Tyrosine Kinase; survival aspects; DNA Repair; 蛋白质酪氨酸激酶; DNA修复;

机译：amidation/deamidation;Protein-Tyrosine Kinase;survival aspects;DNA Repair;蛋白质酪氨酸激酶;DNA修复;

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1. Oncogenic tyrosine kinases, DNA repair and survival: the role of Bcl-xL deamidation in transformation and genotoxic therapies. [J] . Alexander DR Cell cycle . 2004,第5期

机译：致癌酪氨酸激酶，DNA修复和存活：Bcl-xL脱酰胺作用在转化和基因毒性治疗中的作用。
2. An oncogenic tyrosine kinase inhibits DNA repair and DNA-damage-induced Bcl-xL deamidation in T cell transformation. [J] . Zhao R, Yang FT, Alexander DR Cancer Cell . 2004,第1期

机译：致癌酪氨酸激酶在T细胞转化中抑制DNA修复和DNA损伤诱导的Bcl-xL脱酰胺作用。
3. Fusion oncogenic tyrosine kinases alter DNA damage and repair after genotoxic treatment: role in drug resistance? [J] . Hoser G, Majsterek I, Romana DL, Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2003,第3期

机译：融合致癌酪氨酸激酶在遗传毒性治疗后改变DNA损伤和修复：在耐药中起作用？
4. Carboxyl Group Footprinting MS Provides Structural Insights into Inter- and Intramolecular Interactions of the Oncogenic HER2-HER3 Receptor Tyrosine Kinase Heterodimer [C] . Timothy S. Collier, John D. Monsey, Ron Bose American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：羧基脚印MS为致癌癌癌患者的间晶酶激酶异二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二草的结构见解提供结构洞察力
5. The Role Of Polo-Like-Kinase 1 In The Survival Of DNA Repair Deficient Yeast, After Genotoxic Exposure To Hexavalent Chromium. [D] . Prabhala, Harish. 2012

机译：六价铬遗传毒性暴露后，Polo样激酶1在DNA修复缺陷型酵母的存活中的作用。
6. Oncogenic Tyrosine Kinases Target Dok-1 for Ubiquitin-Mediated Proteasomal Degradation To Promote Cell Transformation [O] . Justyna A. Janas, Linda Van Aelst 2011

机译：致癌酪氨酸激酶靶向Dok-1的泛素介导的蛋白酶体降解以促进细胞转化。
7. An oncogenic tyrosine kinase inhibits DNA repair and DNA-damage-induced Bcl-xL deamidation in T cell transformation [O] . Zhao Rui, Yang Feng Tang, Alexander Denis R. 2004

机译：致癌酪氨酸激酶抑制T细胞转化中DNA修复和DNA损伤诱导的Bcl-xL脱酰胺

Oncogenic tyrosine kinases, DNA repair and survival: the role of Bcl-xL deamidation in transformation and genotoxic therapies.

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