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Connecting polarized cytokinesis to epithelial architecture

机译:将极化胞质分裂连接到上皮结构

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Epithelial cells are organized into polarized sheets that separate distinct compartments of multicellular organisms. Within the epithelial tissue, cells are held together by a set of polarized junctional complexes that regulate adhesion and also separate functionally distinct apical and basolateral membranes. Despite a solid understanding of the establishment of apico-basal polarity and of the remodeling of cell-cell contacts during morphogenesis (reviewed in ref. 1), the interplay between polarized adhesion and epithelial cell division is relatively unexplored. In a recent study, we examined this process using live imaging of the Drosophila follicle epithelium.
机译:上皮细胞被组织成极化的薄片,将多细胞生物的不同隔室分开。在上皮组织内,细胞通过一组极化的连接复合物保持在一起,这些复合物调节粘附力,并且还分离功能不同的顶膜和基底外侧膜。尽管对apico-基底极性的建立和形态发生过程中细胞间接触的重塑有深入的了解(参见参考文献1),但极化黏附和上皮细胞分裂之间的相互作用尚未得到充分研究。在最近的研究中,我们使用果蝇卵泡上皮的实时成像检查了这一过程。

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