Gfi1: A unique controller of Treg cells

ShiL.Z.; ChiH.

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Gfi1: A unique controller of Treg cells

机译：Gfi1：Treg细胞的独特控制器

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Regulatory T cells (T_(reg)), defined by the expression of the transcription factor Foxp3, are crucial for immunological self-tolerance and homeostasis. T_(reg) cells are mainly developed in the thymus as natural T_(reg) cells (nT_(reg)), which can be best depicted by a 2-step model. The initial signals from the high-affinity T-cell receptor (TCR) and CD28 co-stimulation lead to the generation of a precursor population with enhanced cytokine responsiveness, which then responds to signals from gammac-dependent cytokines, especially IL-2 for full induction of Foxp3 expression.

机译：调节性T细胞（T_（reg）），由转录因子Foxp3的表达定义，对于免疫自耐受和体内平衡至关重要。 T_（reg）细胞主要作为天然T_（reg）细胞（nT_（reg））在胸腺中发育，这可以通过两步模型来最好地描述。来自高亲和力T细胞受体（TCR）和CD28共同刺激的初始信号导致生成具有增强的细胞因子反应性的前体群体，然后其响应来自gammac依赖性细胞因子（特别是IL-2）的信号Foxp3表达的诱导。

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《Cell cycle》 |2013年第23期|共2页
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ShiL.Z.; ChiH.;
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正文语种 eng
中图分类细胞生物学;
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专利

1. Gfi1: A unique controller of Treg cells [J] . ShiL.Z., ChiH. Cell cycle . 2013,第23期

机译：Gfi1：Treg细胞的独特控制器
2. Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL. [J] . Baatar D, Olkhanud P, Sumitomo K, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第8期

机译：人外周血T调节细胞（Tregs），功能引发的CCR4 + Treg和未引发的CCR4- Tregs使用FasL调节效应T细胞。
3. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells [J] . Loretta L. Doan, Susan D. Porter, Zhijun Duan, Nucleic Acids Research . 2004,第8期

机译：GFI1和GFI1B在淋巴样细胞中靶向靶向抑制Gfi1的转录
4. A unique model of Characterization performance estimation of various solar photovoltaic cells/modules using Microcontroller [C] . Naskar Rakesh, Das Partha, Mandal Ratan 2014 1st International Conference on Non Conventional Energy : Search for Clean amp; Safe Energy . 2014

机译：使用微控制器的各种太阳能光伏电池/模块的特性表征和性能评估的独特模型
5. B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell-dominant T cell responses via IL-33 [D] . Arima, Hiroshi 2019

机译：Notch1信号异常激活的B细胞通过IL-33促进Treg和Th2细胞主导的T细胞反应
6. Relationships between IL-17+ Subsets Tregs and pDCs That Distinguish among SIV Infected Elite Controllers Low Medium and High Viral Load Rhesus Macaques [O] . Ladawan Khowawisetsut, Kovit Pattanapanyasat, Nattawat Onlamoon, -1

机译：IL-17 +子集Treg和pDC之间的关系可区分SIV感染的精英控制者低中和高病毒载量猕猴
7. Relationships between IL-17(+) subsets, Tregs and pDCs that distinguish among SIV infected elite controllers, low, medium and high viral load rhesus macaques. [O] . Ladawan Khowawisetsut, Kovit Pattanapanyasat, Nattawat Onlamoon, 2013

机译：IL-17（+）亚群，Tregs和pDC之间的关系，区分sIV感染的精英控制者，低，中和高病毒载量恒河猴。

Gfi1: A unique controller of Treg cells

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