...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >CDK5: A new lead to survival
【24h】

CDK5: A new lead to survival

机译：CDK5：生存的新途径

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The protein kinase CDK5 was originally discovered at a time when cyclin-depen-dent kinases were thought to be involved exclusively in cell cycle control. The CDK5 catalytic subunit was first identified based on its nucleotide sequence homology to other known CDK family members (cdc2, CDK2), while the enzyme activity was identified by protein purification of a tau kinase relevant to Alzheimer disease and, independently, of a novel kinase exhibiting cdc2-like substrate specificity in brain. These activities were referred to as tau kinase II and brain proline-directed kinase, respectively, which, upon purification were shown to be one and the same enzyme. In addition to isolation of the active form of CDK5, purification revealed a bound p25 regulatory subunit of novel sequence, and molecular cloning revealed the full-length precursor of this subunit, p35.
机译：蛋白激酶CDK5最初是在认为细胞周期蛋白依赖性激酶仅参与细胞周期控制的时候发现的。首先根据其与其他已知CDK家族成员（cdc2，CDK2）的核苷酸序列同源性鉴定CDK5催化亚基，同时通过蛋白质纯化与阿尔茨海默氏病有关的tau激酶和独立于新型激酶的酶活性来鉴定CDK5催化亚基。在大脑中表现出类似cdc2的底物特异性。这些活性分别称为tau激酶II和脑脯氨酸导向的激酶，纯化后显示它们是一种且是相同的酶。除了分离出CDK5的活性形式外，纯化还揭示了新序列中结合的p25调控亚基，分子克隆揭示了该亚基的全长前体p35。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号