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首页> 外文期刊>Cell cycle >Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
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Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

机译：胰腺癌依靠新的谷氨酰胺代谢途径维持氧化还原平衡

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摘要

The metabolic requirements of a proliferating cell differ from those of a cell in homeostasis.1 In order for a cell to duplicate, it must double its genome, protein content and lipid mass. This process requires energy in the form of ATP and NADPH. However, unlike ATP, the amount of NADPH required for biosynthesis is much greater than that needed for homeostasis, which makes the generation of NADPH rate limiting for cellular proliferation. NADPH is used for both macromolecular biosynthesis (e.g., lipids and deoxynucleotide triphosphates) and the maintenance of a reduced intracellular environment.2 Given this dual role, when the demand for NADPH is high (e.g., during proliferation), moderate impacts on NADPH production challenge the maintenance of redox control.
机译：增殖细胞的代谢要求与动态平衡细胞的代谢要求不同。1为了使细胞复制，它必须使其基因组，蛋白质含量和脂质质量增加一倍。此过程需要ATP和NADPH形式的能量。但是，与ATP不同，生物合成所需的NADPH量远大于体内平衡所需的NADPH量，这使NADPH生成速率限制了细胞增殖。 NADPH既用于大分子生物合成（例如脂质和三磷酸脱氧核苷酸），又用于维持减少的细胞内环境。2鉴于这种双重作用，当对NADPH的需求很高时（例如在增殖过程中），对NADPH生产挑战的影响中等维护氧化还原控制。

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