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首页> 外文期刊>Cell cycle >Geminin's double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation.
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Geminin's double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation.

机译：Geminin的双重寿命：染色质连接在从增殖到分化的过渡过程中调节转录。

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摘要

During embryonic development, transitions between cellular programs regulating progenitor cell proliferation and differentiation must be precisely coordinated and temporally controlled to ensure that a proper number of cells are allocated to various structures. The novel coiled-coil protein Geminin was previously characterized as a dual function molecule with roles both in maintenance of genome integrity through regulation of DNA replication licensing and in control of neural cell fate during embryonic development. However, the mechanistic basis of Geminin's activities during embryogenesis and the connections to its cell cycle regulatory role were unknown. Recently, some of Geminin's activities in regulating transcription were shown to occur through interactions with Brg1, the catalytic subunit of the SWI/SNF chromatin-remodeling complex. During development of the nervous system, Geminin controls the transition from proliferating precursor to differentiated post-mitotic neuron by modulating interactions between SWI/SNF and bHLH transcription factors that are critical for neurogenesis. In other developmental contexts, Geminin mediates proliferative-differentiative transitions through interactions with Six3 nd Hox transcription factors and Polycomb Group proteins. Interactions of Geminin with Polycomb and SWI/SNF complex proteins link its transcriptional activities to modulation of chromatin structure. Here we incorporate recent findings regarding Geminin's regulatory roles in coordinating proliferation and differentiation during embryogenesis.
机译：在胚胎发育过程中，调节祖细胞增殖和分化的细胞程序之间的过渡必须精确协调并在时间上加以控制，以确保将适当数量的细胞分配给各种结构。新型卷曲螺旋蛋白Geminin先前被表征为双重功能分子，其作用是通过调节DNA复制许可来维持基因组完整性，以及在胚胎发育过程中控制神经细胞命运。然而，Geminin在胚胎发生过程中活动的机制基础及其与其细胞周期调节作用的联系尚不清楚。最近，Geminin在调节转录中的一些活性被证明是通过与SWI / SNF染色质重塑复合体的催化亚基Brg1相互作用而发生的。在神经系统发育过程中，Geminin通过调节SWI / SNF和对神经发生至关重要的bHLH转录因子之间的相互作用，控制从增殖的前体到分化的有丝分裂后神经元的过渡。在其他发展环境中，Geminin通过与Six3nd Hox转录因子和Polycomb Group蛋白的相互作用介导增殖-分化过渡。 Geminin与Polycomb和SWI / SNF复合蛋白的相互作用将其转录活性与染色质结构的调节联系起来。在这里，我们结合了有关Geminin在胚胎发生过程中协调增殖和分化中的调节作用的最新发现。

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