The fission yeast APC activator Ste9 is regulated by mRNA decay.

Alvarez B; Blanco MA; Moreno S

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The fission yeast APC activator Ste9 is regulated by mRNA decay.

机译：裂变酵母APC激活剂Ste9受mRNA衰减的调节。

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Fission yeast Ste9/Srw1 is a family member of the Fizzy-related APC activators that promote the ubiquitination and degradation of mitotic cyclins and other substrates at the end of mitosis and G1. These proteins are highly regulated during the cell cycle at the level of gene transcription and protein phosphorylation in order to guarantee the correct order of events during the cell cycle. Here we propose mRNA decay as a novel mechanism that regulates ste9+ gene expression during the cell cycle. We have characterized the elements in the 3'UTR of the ste9 mRNA responsible for this mechanism. Moreover, we demonstrate that the instability of ste9 mRNA is important for downregulating Ste9 levels in G2, allowing appropriate cyclin B accumulation to promote timely entry into mitosis.

机译：裂变酵母Ste9 / Srw1是Fizzy相关APC激活剂的家族成员，可在有丝分裂和G1结束时促进有丝分裂细胞周期蛋白和其他底物的泛素化和降解。这些蛋白在细胞周期中受到基因转录和蛋白磷酸化水平的高度调节，以保证在细胞周期中事件的正确顺序。在这里我们提出了mRNA衰变作为调节细胞周期中ste9 +基因表达的新机制。我们已经表征了负责此机制的ste9 mRNA的3'UTR中的元素。此外，我们证明了ste9 mRNA的不稳定性对于下调G2中Ste9的水平非常重要，允许适当的细胞周期蛋白B积累以促进及时进入有丝分裂。

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《Cell cycle》 |2006年第8期|共4页
作者
Alvarez B; Blanco MA; Moreno S;
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正文语种 eng
中图分类细胞生物学;
关键词
Cell Cycle Proteins; Gene Expression Regulation; Fungal; RNA; Messenger; 细胞周期蛋白质类; 基因表达调控; 真菌; RNA; 信使;

机译：Cell Cycle Proteins;Gene Expression Regulation;Fungal;RNA;Messenger;细胞周期蛋白质类;基因表达调控;真菌;RNA;信使;

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1. The fission yeast APC activator Ste9 is regulated by mRNA decay. [J] . Alvarez B, Blanco MA, Moreno S Cell cycle . 2006,第8期

机译：裂变酵母APC激活剂Ste9受mRNA衰减的调节。
2. DISTINCT SUBUNIT FUNCTIONS AND CELL CYCLE REGULATED PHOSPHORYLATION OF 20S APC/CYCLOSOME REQUIRED FOR ANAPHASE IN FISSION YEAST [J] . Yamada H., Yanagida M., Kumada K. Journal of Cell Science . 1997,第Pta15期

机译：裂变酵母中要求分离的20S APC /循环的明显亚单位功能和细胞周期调控的磷酸化
3. Cyclin-Dependent Kinase 9 (Cdk9) of Fission Yeast Is Activated by the CDK-Activating Kinase Csk1, Overlaps Functionally with the TFIIH-Associated Kinase Mcs6, and Associates with the mRNA Cap Methyltransferase Pcm1 In Vivo [J] . Yi Pei, Hongyan Du, Juliet Singer, Molecular and Cellular Biology . 2006,第3期

机译：裂变酵母的细胞周期蛋白依赖性激酶9（Cdk9）被CDK激活激酶Csk1激活，与TFIIH相关的激酶Mcs6重叠，并与mRNA帽甲基转移酶Pcm1体内结合
4. Interleukin-4 Regulates the Expression of Thymus-and Activation-Regulated Chemokine (TARC)/CCL17 by a Signal Transducer and Activator of Transcription 6 (STAT6)-Dependent Mechanism [C] . J. Horejs-Hoeck, G. Wirnsberger, D. Hebenstreit, Collegium Internationale Allergologicum . 2007

机译：白细胞介素-4调节胸腺和活化调节的趋化因子（TARC）/ CCL17的表达通过转录6（STAT6） - 依赖机构的信号传感器和活化剂
5. Selective translation and regulated decay of yeast mRNAs in response to carbon source: cis elements and trans factors [D] . de la Cruz, Bernard Jorque 2000

机译：响应碳源的酵母mRNA的选择性翻译和调控的衰变：顺式元素和反式因子
6. Apc10 and Ste9/Srw1 two regulators of the APC-cyclosome as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast. [O] . K Kominami, H Seth-Smith, T Toda 1998

机译：Apc10和Ste9 / Srw1APC环体的两个调节剂以及CDK抑制剂Rum1对于裂变酵母中G1细胞周期的阻滞是必需的。
7. The Fission Yeast APC Activator Ste9 is Regulated by mRNA Decay [O] . Álvarez, Beatriz, Blanco, Miguel, Moreno, Sergio 2012

机译：裂变酵母APC激活剂Ste9受mRNA衰减的调节

The fission yeast APC activator Ste9 is regulated by mRNA decay.

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