Gene expression sigantures, cancer cell evolution and metastatic progression.

Klein CA

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Gene expression sigantures, cancer cell evolution and metastatic progression.

机译：基因表达特征，癌细胞进化和转移进程。

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Global gene expression profiling and molecular cytogenetics for single cells provide new opportunities to resolve important questions, such as the mechanisms of tumor cell selection during cancer progression. While gene expression analyses show that metastatic progression correlates with the deregulation of certain gene sets in the primary tumor, the direct analysis of disseminated cancer cells, the putative precursors of metachronous metastases, suggests that dissemination is a very early event in the genetic development of human cancers.

机译：单细胞的整体基因表达谱分析和分子细胞遗传学研究为解决重要问题提供了新的机会，例如癌症发展过程中肿瘤细胞选择的机制。尽管基因表达分析表明转移进展与原发肿瘤中某些基因集的失调有关，但对已扩散的癌细胞（即转移性的假定前体）的直接分析表明，扩散是人类遗传发展中的一个非常早期的事件。癌症。

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《Cell cycle》 |2004年第1期|共3页
作者
Klein CA;
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正文语种 eng
中图分类细胞生物学;
关键词
Breast Neoplasms; Colorectal Neoplasms; Evolution; Molecular; Gene Expression Regulation; Neoplastic; 乳腺肿瘤; 结肠直肠肿瘤; 进化; 分子; 基因表达调控; 肿瘤;

机译：Breast Neoplasms;Colorectal Neoplasms;Evolution;Molecular;Gene Expression Regulation;Neoplastic;乳腺肿瘤;结肠直肠肿瘤;进化;分子;基因表达调控;肿瘤;

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专利

1. Gene expression sigantures, cancer cell evolution and metastatic progression. [J] . Klein CA Cell cycle . 2004,第1期

机译：基因表达特征，癌细胞进化和转移进程。
2. Effects of selenomethionine on the gene expression profile of cloned human prostate cancer cells representing a phenotypic continuum of cancer progression. [J] . Stewart J, Ware J, Boysen C, Nutrition and Cancer: An International Journal . 2008,第6期

机译：硒代蛋氨酸对代表人类癌症进展表型连续体的克隆人前列腺癌细胞基因表达谱的影响。
3. MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression. [J] . Szmulewitz RZ, Clark R, Lotan T, International Journal of Cancer =: Journal International du Cancer . 2012,第3期

机译：MKK4通过细胞周期进程的短暂损伤抑制多种高度转移性前列腺癌细胞系的转移定殖。
4. Lipidomic Classification of Human Mammary Cancer Cells According to Metastatic Potential and Oncogene Expression by Desorption Electrospray Ionization Mass Spectrometry [C] . Heather M. Robison, Troy J. Comi, Seung W. Ryu, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：通过解吸电喷雾电离质谱法根据转移电位和癌基因表达的人乳腺癌细胞的脂质化分类
5. Extracellular Matrix Stiffness Dictates Changes in Gene Expression During Breast Cancer Progression. [D] . Carrillo, Esteban R. 2015

机译：细胞外基质的硬度决定了乳腺癌进展过程中基因表达的变化。
6. Growth factor steroid and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. [O] . E A Musgrove, J A Hamilton, C S Lee, 1993

机译：生长因子类固醇和类固醇拮抗剂对细胞周期蛋白基因表达的调节与T-47D人乳腺癌细胞周期进展的变化有关。
7. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. [O] . Che-Ming Liu, Chia-Ling Hsieh, Yun-Chi He, 2013

机译：使用慢病毒递送的shRNa体内靶向aDam9基因表达通过调节REG4依赖性细胞周期进展来抑制前列腺癌生长。
8. Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core [R] . Ross, R. R. , Reichardt, J. , Coetzee, G. A. , 2002

机译：跨越种族的前列腺癌进展的分子决定因素。项目a - 人类5RD5a2基因和前列腺癌进展。项目B - 雄激素受体（aR）在前列腺癌进展中的信号传导。项目C - 前列腺癌进展核心的细胞和分子标记 - 流行病学核心

Gene expression sigantures, cancer cell evolution and metastatic progression.

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