Efficiency, fidelity and enzymatic switching during translesion DNA synthesis.

McCulloch SD; Kokoska RJ; Kunkel TA

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Efficiency, fidelity and enzymatic switching during translesion DNA synthesis.

机译：病变DNA合成过程中的效率，保真度和酶促转换。

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More than half of the 16 human DNA polymerases may have some role in DNA replication and potentially modulate the biological effects of DNA template lesions that impede replication fork progression. As one approach to understand how multiple polymerases are coordinated at the fork, we recently quantified the efficiency and fidelity with which one particular translesion synthesis enzyme, human DNA polymerase eta, copies templates containing cis-syn thymine dimers. Several observations from that study were unanticipated. Here we discuss the structural and biological implications of those results in light of earlier studies of translesion synthesis.

机译：16种人类DNA聚合酶中有一半以上可能在DNA复制中具有一定作用，并可能调节DNA模板损伤的生物学效应，从而阻止复制叉的发展。作为了解多种聚合酶如何在叉子处进行协调的一种方法，我们最近量化了一种特定的病灶转移合成酶（人类DNA聚合酶eta）复制包含顺式-胸腺嘧啶二聚体的模板的效率和保真度。这项研究的一些观察结果是出乎意料的。在这里，我们根据跨病变合成的早期研究讨论这些结果的结构和生物学意义。

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《Cell cycle》 |2004年第5期|共4页
作者
McCulloch SD; Kokoska RJ; Kunkel TA;
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正文语种 eng
中图分类细胞生物学;
关键词
loyalty; DNA synthesis; Human; Efficiency; 效率;

机译：loyalty;DNA synthesis;Human;Efficiency;效率;

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1. Efficiency, fidelity and enzymatic switching during translesion DNA synthesis. [J] . McCulloch SD, Kokoska RJ, Kunkel TA Cell cycle . 2004,第5期

机译：病变DNA合成过程中的效率，保真度和酶促转换。
2. How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis? [J] . Fischhaber PL, Friedberg EC DNA repair . 2005,第2期

机译：在转移DNA合成过程中，如何选择高保真聚合酶并转换成专用（低保真）真核生物聚合酶？
3. Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis. [J] . E S Szekeres, R Woodgate, C W Lawrence Journal of bacteriology . 1996,第9期

机译：用mucAB或rumAB替代umuDC可以改变由位点特异性T-T环丁烷二聚体诱导的两类突变的相对频率，以及跨病变DNA合成的效率。
4. Fast Switching Charge Dump assisted Class-D Audio Amplifier with high Fidelity and high Efficiency [C] . Kwang-Chan Lee, Chang-Seok Chae, Kang-Ho Lee, IEEE Power Electronics Specialists Conference . 2008

机译：快速开关充电转储辅助D类音频放大器具有高保真和高效率
5. DNA replication past bulky carcinogenic DNA adducts: Importance of Escherichia coli DNA polymerase I (KF) sub-domains in translesion DNA synthesis. [D] . Deslich, Jeanne M. 2005

机译：通过大量致癌的DNA加合物进行的DNA复制：跨病变DNA合成中大肠杆菌DNA聚合酶I（KF）子域的重要性。
6. Enzymatic switching for efficient and accurate translesion DNA replication [O] . Scott D. McCulloch, Robert J. Kokoska, Olga Chilkova, 2004

机译：酶促切换可实现高效准确的跨病变DNA复制
7. Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis. [O] . Szekeres, E S, Woodgate, R, Lawrence, C W 1996

机译：用mucAB或rumAB替代umuDC可以改变由位点特异性T-T环丁烷二聚体诱导的两类突变的相对频率，以及跨病变DNA合成的效率。

Efficiency, fidelity and enzymatic switching during translesion DNA synthesis.

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