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首页> 外文期刊>Radiology >Cerebral metabolite patterns in dialysis patients: evaluation with H-1 MR spectroscopy.
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Cerebral metabolite patterns in dialysis patients: evaluation with H-1 MR spectroscopy.

机译：透析患者的脑代谢物模式：H-1 MR光谱法评估。

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摘要

PURPOSE: To analyze metabolic changes in the brain of patients undergoing dialysis. MATERIALS AND METHODS: Sixteen patients undergoing hemodialysis, 10 patients undergoing continuous ambulatory peritoneal dialysis (CAPD), and 42 healthy volunteers underwent magnetic resonance (MR) spectroscopy and MR imaging. Spectra were obtained from one occipital gray matter voxel and one parietal white matter voxel. Changes in N-acetylaspartate (NAA), choline (Cho), myo-inositol and glycine (Myo), and creatine (Cr) were analyzed and the results presented as ratios, with Cr as the reference. RESULTS: Three abnormalities were observed in the spectra of the hemodialysis patients: (a) significant elevation of the Cho/Cr ratio in gray matter, (b) significant elevation of the Myo/Cr ratio in gray matter, and (c) significant reduction of the NAA/Cr ratio in gray and white matter. The strongest metabolic alterations were found in cortical gray matter. In CAPD patients, only gray matter Cho/Cr ratio was significantly elevated. An increased frequency of focal white matter lesions was observed on MR images in the dialysis patients. CONCLUSION: Proton MR spectroscopy is useful for in vivo monitoring of metabolic alterations in the brain due to chronic dialysis.
机译：目的：分析接受透析的患者大脑中的代谢变化。材料与方法：16例接受血液透析的患者，10例接受连续非卧床腹膜透析（CAPD）的患者以及42例健康志愿者接受了磁共振波谱（MR）和MR成像。从一个枕骨灰质体素和一个顶叶白质体素获得光谱。分析了N-乙酰天门冬氨酸（NAA），胆碱（Cho），肌醇和甘氨酸（Myo）和肌酸（Cr）的变化，结果以比率表示，以Cr为参考。结果：血液透析患者的光谱中观察到三个异常：（a）灰质中Cho / Cr比值显着升高;（b）灰质中Myo / Cr比值显着升高;（c）显着降低和白质中的NAA / Cr比值在皮质灰质中发现最强的代谢改变。在CAPD患者中，仅灰质Cho / Cr比显着升高。在透析患者的MR图像上观察到局灶性白质病变的频率增加。结论：质子核磁共振波谱可用于体内监测慢性透析引起的大脑代谢变化。

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