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首页> 外文期刊>Livestock Science >The effect of administration of 2-iminobiotin at birth on growth rates, morbidity and mortality in piglets under farm conditions
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The effect of administration of 2-iminobiotin at birth on growth rates, morbidity and mortality in piglets under farm conditions

机译：农场条件下出生时施用2-亚氨基生物素对仔猪生长速度，发病率和死亡率的影响

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It has since long been demonstrated that perinatal asphyxia in pigs can result in perinatal mortality, decreased viability/vitality at birth and reduced survival rates until 10 days of age. In human perinatology much interest is presently focussed on strategies to prevent adverse outcome arising from birth asphyxia. Given the rather high perinatal and postnatal losses in the pig industry, it is very interesting to explore rescue strategies to reduce adverse effects of postischemic organ damage caused by perinatal asphyxia also in newborn piglets. The aim of this study was to determine the effects of postnatal treatment of piglets with 2-IminoBiotin (2-IB), a selective inhibitor of neuronal and inducible NitricOxideSynthase (nNOS and iNOS), under farm conditions on postnatal growth rates, morbidity and mortality. In total 81 piglets from 15 litters were used. Immediately after birth, blood was collected from the umbilical artery and piglets were alternately assigned to either a control (saline) or drug (2-IB; 0.18 mg/kg bodyweight every 4 h during 24 h) group. Administration of control or drug started with an intravenous injection in the umbilical vein immediately after birth, followed by 6 intraperitoneal injections at 4 h intervals, starting 4 h after the intravenous injection. Piglets were checked for growth, morbidity and mortality until the experiment was finished (average age: 44 days). Postnatal treatment with 2-IB resulted in significantly increased growth rates at 10 days of age (P =0.02) (165 g/day compared to 140 g/day in controls), independently of health status and birth weight. At weaning 2-IB treated piglets tended to show higher growth rates (P =0.06). Growth rates at the end of the experiment, morbidity and mortality were not affected by treatment. It is hypothesized that 2-IB reduces the rather limited, nearly 'physiological' harmful effects occurring in the gastrointestinal tract, resulting from a short period of hypoxia-ischemia experienced during birth. This might explain the significantly increased growth rates at 10 days of life in 2-IB treated piglets. Selective inhibition of nNOS and iNOS might also result in increased availability of l-arginine for protein synthesis in newborns resulting in higher postnatal growth rates. However these issues need further investigations. In conclusion, this study showed a positive effect of immediate postpartum administration of 2-IB during the first day after birth on growth rates up to 10 days of age. Furthermore, no negative effects of 2-IB treatment on piglet health and survival were found.
机译：长期以来一直证明，猪的围产期窒息可导致围产期死亡，出生时存活力/活力下降以及成年后10天存活率降低。在人类围手术学中，目前人们将很多兴趣集中在防止因出生窒息而引起的不良后果的策略上。考虑到养猪业围产期和产后损失相当高，探索挽救策略以减少新生仔猪围产期窒息引起的缺血后器官损害的不良影响非常有趣。这项研究的目的是确定在农场条件下用2-IminoBiotin（2-IB）（一种神经元和诱导型一氧化氮合酶（nNOS和iNOS）的选择性抑制剂）对仔猪进行产后处理对产后生长率，发病率和死亡率的影响。总共使用了来自15窝的81头仔猪。出生后立即从脐动脉采血，将仔猪交替分配至对照组（盐水）或药物（2-IB;每24小时内每4小时0.18 mg / kg体重）组。对照组或药物的给药始于出生后立即在脐静脉内静脉注射，然后以4小时的间隔进行6次腹膜内注射，从静脉注射后4小时开始。检查仔猪的生长，发病率和死亡率，直到实验结束（平均年龄：44天）。 2-IB的产后治疗可导致10天大的生长速度显着增加（P = 0.02）（165 g /天，而对照组为140 g /天），而与健康状况和出生体重无关。断奶的2-IB处理的仔猪倾向于显示较高的生长速度（P = 0.06）。实验结束时的生长率，发病率和死亡率不受治疗的影响。假设2-IB减少了出生时经历的短暂缺氧缺血导致的在胃肠道中发生的相当有限的，几乎“生理”的有害作用。这可以解释2-IB处理的仔猪在生命10天时的生长速度显着增加。对nNOS和iNOS的选择性抑制也可能导致l-精氨酸在新生儿蛋白质合成中的可用性增加，从而导致更高的出生后生长速度。但是，这些问题需要进一步调查。总之，这项研究表明，在出生后第一天立即产后服用2-IB对10天以下的生长率具有积极作用。此外，未发现2-IB治疗对仔猪健康和生存的负面影响。

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