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Comparing plasma cortisol and behaviour of calves dehorned with caustic paste after non-steroidal-anti-inflammatory analgesia

机译:非甾体类抗炎镇痛后血浆皮质醇和用苛性糊剂脱角的小牛行为的比较

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Caustic paste is frequently used for disbudding young female dairy calves. Nerve blocking may not be completely effective after such chemical tissue damage. Regional anaesthesia, together with a non-steroidal-anti-inflammatory drug (NSAID), was shown to reduce plasma cortisol in calves disbudded using caustic paste. To find out whether pre-emptive NSAID alone could control pain or whether NSAID reduces cortisol response by a mechanism other than by pain control, we compared cortisol levels and behaviour of 10 chemically disbudded calves treated with IV flunixin-meglumine, five of which were injected at 5 min (F0) and five injected at 60 min before dehorning (F1), with 5 sham-dehorned (ND) and 5 non-treated chemically disbudded animals (CD). There was a higher (p <0.001) cortisol level in both NSAID-treated groups compared with ND at 1 h after disbudding, but no differences from control animals (CD). Non-treated disbudded animals showed higher cortisol at +3 h compared with ND. A higher incidence of pain-related behaviours was shown in disbudded animals up to 3 h post-disbudding. We conclude that pre-emptive analgesia treatment by itself is not effective in controlling pain and does not prevent blood cortisol increase after disbudding of calves with caustic paste.
机译:苛性糊剂通常用于排出年轻的雌性乳牛犊。在此类化学组织损伤后,神经阻滞可能并不完全有效。局部麻醉与非甾体抗炎药(NSAID)一起使用可减少使用苛性糊剂剥夺的小牛的血浆皮质醇。为了了解仅先发制人的非甾体抗炎药是否可以控制疼痛,或者非甾体抗炎药可以通过除疼痛控制以外的其他机制降低皮质醇反应,我们比较了用氟利辛-葡甲胺静脉注射治疗的10只化学上无预算的小牛的皮质醇水平和行为,其中五种已注射在第5分钟(F0)时,在脱喇叭(F1)之前60分钟注射五只,与5只假脱角(ND)和5只未经处理的化学未处理动物(CD)注射。出院后1 h,两个NSAID治疗组的皮质醇水平均高于ND(p <0.001),但与对照动物(CD)没有差异。与ND相比,未经治疗的预算外动物在+3 h时皮质醇含量更高。在出胎后3小时内,失龄动物中与疼痛有关的行为发生率更高。我们得出的结论是,先发制人的镇痛治疗本身并不能有效控制疼痛,也不能防止在用牛油膏涂抹小牛后血液中的皮质醇增加。

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