• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >Preserved MHC-II antigen processing and presentation function in chronic HCV infection.
【24h】

Preserved MHC-II antigen processing and presentation function in chronic HCV infection.

机译：在慢性HCV感染中保留了MHC-II抗原的加工和呈递功能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Individuals with chronic HCV infection have impaired response to vaccine, though the etiology remains to be elucidated. Dendritic cells (DC) and monocytes (MN) provide antigen uptake, processing, presentation, and costimulatory functions necessary to achieve optimal immune responses. The integrity of antigen processing and presentation function within these antigen presenting cells (APC) in the setting of HCV infection has been unclear. We used a novel T cell hybridoma system that specifically measures MHC-II antigen processing and presentation function of human APC. Results demonstrate MHC-II antigen processing and presentation function is preserved in both myeloid DC (mDC) and MN in the peripheral blood of chronically HCV-infected individuals, and indicates that an alteration in this function does not likely underlie the defective HCV-infected host response to vaccination.
机译：慢性HCV感染的个体对疫苗的反应受损，尽管病因尚待阐明。树突状细胞（DC）和单核细胞（MN）提供实现最佳免疫反应所必需的抗原摄取，加工，呈递和共刺激功能。在HCV感染的情况下，这些抗原呈递细胞（APC）中抗原加工和呈递功能的完整性尚不清楚。我们使用了一种新型的T细胞杂交瘤系统，专门测量MHC-II抗原加工和人类APC的呈递功能。结果表明，慢性HCV感染者外周血的髓样DC（mDC）和MN中都保留了MHC-II抗原的加工和呈递功能，并且表明该功能的改变可能不是HCV感染缺陷宿主的基础对疫苗的反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号