Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques.

Yang GB; Lei N; Zong CM; Duan JZ; Xing H; Shao Y

首页> 外文期刊>Cellular immunology >Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques.

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Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques.

机译：反复感染中华猕猴的猿猴/人类免疫缺陷病毒（SHIV）和猿猴免疫缺陷病毒（SIV）外周血单个核细胞中CD1c +髓样树突状细胞的频率升高。

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CD1c+ myeloid dendritic cells (mDCs) in the peripheral blood of 30 SHIV-SF162p4 and SIVmac251 sequentially infected Chinese rhesus macaques were examined by flow cytometry to obtain further insight into mDC alterations in HIV/AIDS. The CD1c+ cells were found to be mononuclear leukocytes rather than granulocytes, and most of them expressed CD20. CD1c+mDCs (CD1c+CD20-) consisted of two morphological subsets: the granular and the large CD1c+mDCs. The expression of HLA-DR, CD86, and CD11b, but no CCR7, CD83 and CD123, together with their endocytotic capacity indicated that they were immature mDCs. Their frequency at weeks 10 and 12 post-infection was significantly higher than that of un-infected ones; the large CD1c+mDC level was significantly different between time points and almost absent from un-infected rhesus monkeys; significant correlations between CD1c+mDCs and plasma viral load levels were also observed. These data indicated a possible role for CD1c+mDCs in the pathophysiological process of SIV/HIV infection.

机译：通过流式细胞术检查了依次感染的30只SHIV-SF162p4和SIVmac251猕猴外周血中的CD1c +髓样树突细胞（mDC），以进一步了解mDC改变的HIV / AIDS。发现CD1c +细胞是单核白细胞而不是粒细胞，并且大多数表达CD20。 CD1c + mDC（CD1c + CD20-）由两个形态子集组成：颗粒状和大CD1c + mDC。 HLA-DR，CD86和CD11b的表达，但没有CCR7，CD83和CD123的表达，以及它们的内吞能力表明它们是未成熟的mDC。在感染后第10和12周，它们的频率明显高于未感染的。 CD1c + mDC的大水平在各时间点之间存在显着差异，未感染的恒河猴几乎没有。还观察到CD1c + mDC与血浆病毒载量水平之间存在显着相关性。这些数据表明CD1c + mDC在SIV / HIV感染的病理生理过程中可能发挥作用。

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《Cellular immunology》 |2011年第1期|共8页
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Yang GB; Lei N; Zong CM; Duan JZ; Xing H; Shao Y;
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中图分类细胞生物学;
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1. Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques. [J] . Yang GB, Lei N, Zong CM, Cellular immunology . 2011,第1期

机译：反复感染中华猕猴的猿猴/人类免疫缺陷病毒（SHIV）和猿猴免疫缺陷病毒（SIV）外周血单个核细胞中CD1c +髓样树突状细胞的频率升高。
2. RANTES, IFN-gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph node, and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques. [J] . Cheret A, Le Grand-R, Caufour P, Virology . 1999,第2期

机译：猕猴原发猿猴免疫缺陷病毒感染过程中外周血，淋巴结和支气管肺泡灌洗单核细胞中的RANTES，IFN-γ，CCR1和CCR5 mRNA表达。
3. Functional genomics analyses of differential macaque peripheral blood mononuclear cell infections by human immunodeficiency virus-1 and simian immunodeficiency virus [J] . Li Y, Chan EY, Katze MG Virology . 2007,第1期

机译：人类免疫缺陷病毒-1和猿猴免疫缺陷病毒对猕猴外周血单个核细胞的感染的功能基因组学分析
4. Purification of a Chinteric Simian - Human Immunodeficiency Virus-Like Nanoparticle from HEK293 Cell Culture [C] . Luisa Pedro and Guilherme N. M. Ferreira European Society of Animal Cell Technology . 2010

机译：从HEK293细胞培养物中纯化了含有Chinteric Simian - 人免疫缺陷病毒样纳米粒子
5. The role of the transmembrane and cytoplasmic domains of the VPU protein of human immunodeficiency virus type 1 (HIV-1) in the acute CD4+ T cell loss and disease in the simian human immunodeficiency virus (SHIV)/macaque model. [D] . Hout, David Richard. 2006

机译：人类免疫缺陷病毒1型（HIV-1）的VPU蛋白的跨膜和胞质域在猿猴人类免疫缺陷病毒（SHIV）/猕猴模型的急性CD4 + T细胞丧失和疾病中的作用。
6. T Cell—Tropic Simian Immunodeficiency Virus (SIV) and Simian-Human Immunodeficiency Viruses Are Readily Transmitted by Vaginal Inoculation of Rhesus Macaques and Langerhans’ Cells of the Female Genital Tract Are Infected with SIV [O] . Christopher J. Miller, Jinjie Hu -1

机译：猕猴的阴道接种可迅速传播T细胞—猿猴免疫缺陷病毒（SIV）和猿猴免疫缺陷病毒女性生殖道的朗格汉斯细胞也感染了SIV。
7. T Cell–Tropic Simian Immunodeficiency Virus (SIV) and Simian‐Human Immunodeficiency Viruses Are Readily Transmitted by Vaginal Inoculation of Rhesus Macaques, and Langerhans' Cells of the Female Genital Tract Are Infected with SIV [O] . Christopher J. Miller, Jinjie Hu 1999

机译：T细胞 - 热带猿猴免疫缺陷病毒（SIV）和Simian-人免疫缺陷病毒易于通过阴道接种恒河猴的猕猴，而兰氏植物的植物生殖道细胞感染了SIV
8. Utilization of Simian Immunodeficiency Virus (SIV) Infection for SubhumanPrimates to Evaluate Experimental Chemotherapy and Vaccines. Titration of Two Strains of Simian Immunodeficiency Virus (SIV) in Macaca Mulatta and Tissue Culture [R] . Marx, P. 1992

机译：利用猿猴免疫缺陷病毒（sIV）感染subhumanprimates评估实验性化疗和疫苗。猕猴两种猿猴免疫缺陷病毒（sIV）的滴定及组织培养

Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques.

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