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首页> 外文期刊>Cellular immunology >Identification of novel mimicry epitopes for cardiac myosin heavy chain-alpha that induce autoimmune myocarditis in A/J mice.
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Identification of novel mimicry epitopes for cardiac myosin heavy chain-alpha that induce autoimmune myocarditis in A/J mice.

机译：识别心肌肌球蛋白重链-α的新拟态抗原决定簇，该表位诱导A / J小鼠自身免疫性心肌炎。

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摘要

Myocarditis is one cause of sudden cardiac death in young adolescents, and individuals affected with myocarditis can develop dilated cardiomyopathy, a frequent reason for heart transplantation. Exposure to environmental microbes has been suspected in the initiation of heart autoimmunity, but the direct causal link is lacking. We report here identification of novel mimicry epitopes that bear sequences similar to those in cardiac myosin heavy chain (MYHC)-alpha 334-352. These epitopes represent Bacillus spp., Magnetospirillum gryphiswaldense, Cryptococcus neoformans and Zea mays. The mimicry peptides induced varying degrees of myocarditis in A/J mice reminiscent of the disease induced with MYHC-alpha 334-352. We demonstrate that the mimics induce cross-reactive T cell responses for MYHC-alpha 334-352 as verified by MHC class II IA(k)/tetramer staining and Th-1 and Th-17 cytokines similar to those of MYHC-alpha 334-352. The data suggest that exposure to environmental microbes which are otherwise innocuous can predispose to heart autoimmunity by molecular mimicry.
机译：心肌炎是青少年突然心源性死亡的原因之一，患有心肌炎的个体会发展为扩张型心肌病，这是心脏移植的常见原因。在心脏自身免疫的启动过程中，怀疑与环境微生物接触，但缺乏直接的因果关系。我们在这里报告鉴定具有类似于心肌肌球蛋白重链（MYHC）-alpha 334-352的序列的新型模仿表位的鉴定。这些表位代表芽孢杆菌属，Gryphiswaldense的磁螺旋藻，新隐球菌和玉米。拟肽在A / J小鼠中诱导了不同程度的心肌炎，使人联想到MYHC-alpha 334-352诱导的疾病。我们证明了模仿物诱导了MYHC-α334-352的交叉反应性T细胞反应，这一点已通过MHC II类IA（k）/四聚体染色以及与MYHC-α334-相似的Th-1和Th-17细胞因子进行了验证。 352。数据表明，暴露于原本无害的环境微生物会通过分子模仿而诱发心脏自身免疫。

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