Choice of resident costimulatory molecule can influence cell fate in human naive CD4+ T cell differentiation.

Williams KM; Dotson AL; Otto AR; Kohlmeier JE; Benedict SH

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Choice of resident costimulatory molecule can influence cell fate in human naive CD4+ T cell differentiation.

机译：常驻共刺激分子的选择可影响人类幼稚CD4 + T细胞分化中的细胞命运。

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With antigen stimulation, naive CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naive T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naive CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+CAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.

机译：通过抗原刺激，幼稚的CD4 + T细胞可分化为几个效应子或记忆细胞群，而细胞因子则有助于分化。这些细胞上的几种蛋白质会接受共刺激信号，但是尚未对它们对幼稚T细胞分化的不同作用进行系统比较。比较了驻留在人类幼稚CD4 + T细胞上的两种共刺激蛋白CD28和ICAM-1参与分化的过程。在受控条件下，并且不添加细胞因子，通过CD3 + CD28或CD3 + CAM-1的共刺激诱导分化为T效应细胞和T记忆细胞。相反，通过CD3 + ICAM-1的共刺激可诱导向Treg细胞的分化，而通过CD3 + CD28的共刺激则不会。

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《Cellular immunology》 |2011年第2期|共10页
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Williams KM; Dotson AL; Otto AR; Kohlmeier JE; Benedict SH;
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中图分类细胞生物学;
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1. Choice of resident costimulatory molecule can influence cell fate in human naive CD4+ T cell differentiation. [J] . Williams KM, Dotson AL, Otto AR, Cellular immunology . 2011,第2期

机译：常驻共刺激分子的选择可影响人类幼稚CD4 + T细胞分化中的细胞命运。
2. Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human "naive" and "memory" CD4+ T cells. [J] . R T Semnani, T B Nutman, P Hochman, The Journal of Experomental Medicine . 1994,第6期

机译：纯化的细胞间粘附分子1和淋巴细胞功能相关抗原3的共刺激在人的“天然”和“记忆” CD4 + T细胞中诱导了不同的增殖，细胞因子和细胞表面抗原谱。
3. Endothelial cells provide costimulatory signals to trigger both allogeneic adult and cord blood (NAIVE) CD4+ T-cell proliferation. [J] . Camara NO, Cappellesso S, Watier H, Transplantation Proceedings . 2000,第2期

机译：内皮细胞提供共刺激信号，以触发同种异体成年和脐血（NAIVE）CD4 + T细胞增殖。
4. The high expression level of programmed death-1 ligand 2 in oral lichen planus and the possible costimulatory effect on human T cells [C] . Guan-Huan Du, Xiao-Peng Qin, Qin Li, Academic Committee conference of Shanghai key lab of stomatology . 2011

机译：口腔扁平苔藓中程序性死亡1配体2的高表达水平及其对人T细胞的共刺激作用
5. The Role of T cell Receptor Avidity in Determining T-helper Differentiation Fate of Human CD4+ T cells. [D] . Adair, Patrick. 2016

机译：T细胞受体亲和力在确定人类CD4 + T细胞的T辅助分化命运中的作用。
6. Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation [O] . Kelli M. Williams, Abby L. Dotson, Amber R. Otto, -1

机译：驻留的常规分子的选择可以影响人类天真CD4 + T细胞分化中的细胞命运
7. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection. [O] . Ye, G, Barrera, C, Fan, X, 1997

机译：B7-1和B7-2共刺激分子在人胃上皮细胞中的表达：幽门螺杆菌感染过程中CD4 + T细胞活化的潜在作用。
8. Costimulation of T Cell Receptor/CD3-Mediated Activation of Resting Human CD4+ TCells by Leukocyte Function-Associated Antigen-1 Ligand Intercellular Cell Adhesion Molecule-1 Involves Prolonged Inositol Phospholipid Hydrolysis and Sustained Increase of In [R] . Van Seventer, G. A., Bonvini, E., Yamada, H., 1992

机译：白细胞功能相关抗原-1配体细胞间粘附分子-1的T细胞受体/ CD3介导的静息人CD4 + TCell活化共刺激涉及延长的肌醇磷脂水解和持续增加的In

Choice of resident costimulatory molecule can influence cell fate in human naive CD4+ T cell differentiation.

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