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首页> 外文期刊>Cellular immunology >HIV-1 reactivation in HIV-latently infected dendritic cells by oral microorganisms and LPS.
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HIV-1 reactivation in HIV-latently infected dendritic cells by oral microorganisms and LPS.

机译：通过口腔微生物和LPS在HIV潜伏感染的树突状细胞中激活HIV-1。

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Dendritic cells are critical components of the host defense system that play pivotal role in linking innate immunity to adaptive immune responses. In the role of interfacing with pathogens through the action of surface pattern-recognition receptors, dendritic cells are a potential target for retroviral infection and latency. Dendritic cells are a long-lived reservoir of latent virus in HIV (human immunodeficiency virus)-infected patients. It is hypothesized that HIV-latently infected dendritic cells would be stimulated by oral bacteria leading to reactivation of HIV. In our HIV-latently infected dendritic cell models, of both promoter activation and HIV production, significant differences were observed among the bacterial species in their ability to stimulate HIV reactivation. The experimental data support the hypothesis that oral bacteria related to periodontal infections could trigger latently infected dendritic cells in gingival tissues and contribute to HIV recrudescence and undermining anti-retroviral therapy.
机译：树突状细胞是宿主防御系统的关键组成部分，在将先天性免疫与适应性免疫反应联系起来方面发挥关键作用。树突状细胞通过表面模式识别受体的作用与病原体相互作用，是逆转录病毒感染和潜伏期的潜在靶标。树突状细胞是感染了HIV（人类免疫缺陷病毒）的患者的潜伏病毒的长期保存库。假设口服细菌会刺激HIV潜在感染的树突状细胞，从而导致HIV活化。在我们的HIV潜伏感染的树突状细胞模型中，既有启动子激活又有HIV产生，在细菌物种之间刺激HIV激活的能力方面观察到显着差异。实验数据支持以下假设，即与牙周感染有关的口腔细菌可能会触发牙龈组织中潜伏感染的树突状细胞，并导致HIV复发和破坏抗逆转录病毒疗法。

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