CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.

Rigo M; Chentouf M; Pelegrin A; Chardes T

首页> 外文期刊>Cellular immunology >CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.

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CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.

机译：CD4连接从CD3 / CD28激活的T细胞中的GM1阳性膜筏中排除Carma1-Bcl10-MALT1复合物。

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The antibody 13B8.2, which is directed against the CDR3-like loop on the D1 domain of CD4, induces CD4/ZAP-70 reorganization and ceramide release in membrane rafts. Here, we investigated whether CD4/ZAP-70 compartmentalization could be mediated by an effect of 13B8.2 on the Carma1-Bcl10-MALT1 complex in membrane rafts. We report that treatment of CD3/CD28-activated Jurkat T cells with 13B8.2, but not rituximab, excluded Carma1-Bcl10-MALT1 proteins from GM1(+) membrane rafts and concomitantly decreased NF-kappaB activation. Fluorescence confocal imaging confirmed that Carma1-Bcl10 and Carma1-MALT1 co-patching, observed in GM1(+) membrane rafts following CD3/CD28 activation, were abrogated after a 24h-treatment with 13B8.2. The CD4/ZAP-70 compartmentalization in membrane rafts induced by 13B8.2 is thus related to Carma1-Bcl10-MALT1 raft exclusion.

机译：针对CD4 D1结构域上的CDR3样环的抗体13B8.2诱导膜筏中的CD4 / ZAP-70重组和神经酰胺释放。在这里，我们调查了CD4 / ZAP-70分隔是否可以由13B8.2对膜筏中Carma1-Bcl10-MALT1复合物的作用介导。我们报告说，用13B8.2而不是利妥昔单抗治疗CD3 / CD28激活的Jurkat T细胞，从GM1（+）膜筏中排除Carma1-Bcl10-MALT1蛋白，并同时降低NF-kappaB激活。荧光共聚焦成像证实，在CD3 / CD28激活后的GM1（+）膜筏中观察到的Carma1-Bcl10和Carma1-MALT1共修补在用13B8.2处理24小时后被废除。因此，由13B8.2诱导的膜筏中的CD4 / ZAP-70分隔与Carma1-Bcl10-MALT1筏排阻有关。

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《Cellular immunology》 |2011年第1期|共7页
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Rigo M; Chentouf M; Pelegrin A; Chardes T;
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中图分类细胞生物学;
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1. CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells. [J] . Rigo M, Chentouf M, Pelegrin A, Cellular immunology . 2011,第1期

机译：CD4连接从CD3 / CD28激活的T细胞中的GM1阳性膜筏中排除Carma1-Bcl10-MALT1复合物。
2. Follicular lymphoma intratumoral CD4+CD25+GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25- and CD4+CD25- T cells. [J] . Hilchey SP, De A, Rimsza LM, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第7期

机译：滤泡性淋巴瘤瘤内CD4 + CD25 + GITR +调节性T细胞有效抑制CD3 / CD28共刺激的自体和同种CD8 + CD25-和CD4 + CD25-T细胞。
3. Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells. [J] . Mueller DL, Seiffert S, Fang W, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1996,第5期

机译：CD3，CD28和IL-2受体在克隆的CD4 +辅助T细胞中对bcl-2和bcl-x的差异调节。记忆细胞长期存活的模型。
4. OPTIMIZED PROCESS FOR REGULATORY T CELL ACTIVATION AND EXPANSION USING DYNABEADS~(TM) TREG CD3/CD28 FOR CLINICAL APPLICATIONS [C] . Hui Zhang, Kerstin Bernstrom, Nora Lieske, Scale-up and manufacturing of cell-based therapies V . 2017

机译：使用DYNABEADS〜（TM）TREG CD3 / CD28进行调节性T细胞活化和扩增的最佳方法，用于临床应用
5. The development, activation, function and mechanisms of regulatory alpha-beta-TCR+CD3+CD4-CD8-NK- T cells in the suppression of allogeneic and autologous immune responses. [D] . Ford, Megan S. 2007

机译：调节性α-β-TCR+ CD3 + CD4-CD8-NK-T细胞在同种异体和自体免疫反应抑制中的发展，激活，功能和机制。
6. Gardenia jasminoides extract and its constituent genipin inhibit activation of CD3/CD28 co-stimulated CD4+ T cells via ORAI1 channel [O] . Hyun Jong Kim, Yu Ran Nam, JooHan Woo, 2020

机译：茉莉子提取物及其成分genipin通过ORAI1通道抑制CD3 / CD28共刺激的CD4 + T细胞的活化
7. CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells. [O] . Rigo, Maxime, Chentouf, Myriam, Pèlegrin, André, 2011

机译：CD4连接从CD3 / CD28激活的T细胞中的GM1阳性膜筏中排除Carma1-Bcl10-MALT1复合物。
8. Distinct Signal Transduction in Mouse CD4(+) and CD8(+) Splenic T Cells AfterCD28 Receptor Ligation [R] . Abe, R., Vandenberghe, P., Craighead, N., 1995

机译：CD28受体结扎后小鼠CD4（+）和CD8（+）脾T细胞的不同信号转导

CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.

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