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首页> 外文期刊>Cellular immunology >NKT ligand-loaded, antigen-expressing B cells function as long-lasting antigen presenting cells in vivo.
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NKT ligand-loaded, antigen-expressing B cells function as long-lasting antigen presenting cells in vivo.

机译：NKT配体加载的抗原表达B细胞在体内起着持久的抗原呈递细胞的作用。

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We had previously shown that activated NKT cells licensed B cells to be immunogenic antigen-presenting cells and helped to elicit a wide spectrum of cancer targeted immune responses. In the current study, we sought to verify the safety of alphaGalCer-loaded, and adenovirus-transduced B cell-based vaccines, together with mechanism of action. Intravenously injected alphaGalCer-loaded, antigen-expressing B cells rapidly localized in the spleen and directly primed CD8(+) T cells in an antigen-specific manner. The transferred antigen was sustained for at least 30 days. While some injected B cells produced nonspecific IgG, the antigen-specific IgG response was completely dependent on endogenous B cells. The liver was one of the main tissues where injected B cells were retained; however, we could not find the signs of liver toxicity. Our results demonstrate that alphaGalCer-loaded, antigen-expressing B cells behave as antigen-presenting B cells in vivo without significant toxicity.
机译：先前我们已经证明，活化的NKT细胞许可B细胞成为具有免疫原性的抗原呈递细胞，并有助于引发多种针对癌症的免疫反应。在当前的研究中，我们试图验证装载有alphaGalCer和腺病毒转导的B细胞疫苗的安全性以及作用机理。静脉注射负载alphaGalCer的表达抗原的B细胞迅速定位在脾脏中，并以抗原特异性方式直接引发CD8（+）T细胞。转移的抗原持续至少30天。虽然一些注射的B细胞产生非特异性IgG，但抗原特异性IgG反应完全依赖于内源性B细胞。肝脏是保留注射的B细胞的主要组织之一。但是，我们找不到肝脏毒性的迹象。我们的结果表明，装载alphaGalCer的表达抗原的B细胞在体内表现为呈递抗原的B细胞，而没有明显的毒性。

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