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首页> 外文期刊>Cellular immunology >Burn injury suppresses human dermal dendritic cell and Langerhans cell function.
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Burn injury suppresses human dermal dendritic cell and Langerhans cell function.

机译：烧伤会抑制人的皮肤树突状细胞和朗格汉斯细胞功能。

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摘要

Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering both epidermal LC and dermal DC functions. We developed a human ex vivo burn injury model to study the function of DCs in thermally injured skin. No differences were observed in the capacity of both LCs and dermal DCs to migrate out of burned skin compared to unburned skin. Similarly, expression levels of co-stimulatory molecules were unaltered. Notably, we observed a strong reduction of T cell activation induced by antigen presenting cell (APC) subsets that migrated from burned skin through soluble burn factors. Further analyses demonstrated that both epidermal LCs and dermal DCs have a decreased T cell stimulatory capacity after burn injury. Restoring the T cell stimulatory capacity of DC subsets might improve tissue regeneration in patients with burn wounds.
机译：人体皮肤包含表皮朗格汉斯细胞（LC）和真皮树突状细胞（DC），它们是感染后诱导适应性免疫的关键因素。严重烧伤后，患者的适应性免疫受到抑制。在这里，我们证明烧伤可通过改变表皮LC和皮肤DC功能来影响适应性免疫。我们开发了人类离体烧伤模型，以研究DC在热损伤皮肤中的功能。与未烧伤的皮肤相比，LC和真皮DC从烧伤皮肤中迁移出来的能力均未观察到差异。类似地，共刺激分子的表达水平未改变。值得注意的是，我们观察到抗原呈递细胞（APC）子集从烧伤的皮肤通过可溶性烧伤因子迁移而引起的T细胞活化大大降低。进一步的分析表明，烧伤后表皮LC和真皮DC均具有降低的T细胞刺激能力。恢复DC亚群的T细胞刺激能力可能会改善烧伤患者的组织再生。

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