Increased sensitivity of cholera toxin B treated K562 cells to natural killer cells.

Mrowczynska L; Bobrowska Hagerstrand M; Hagerstrand H; Lindqvist C

首页> 外文期刊>Cellular immunology >Increased sensitivity of cholera toxin B treated K562 cells to natural killer cells.

【24h】

Increased sensitivity of cholera toxin B treated K562 cells to natural killer cells.

机译：霍乱毒素B处理的K562细胞对自然杀伤细胞的敏感性增加。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Cholera toxin B-subunit (CTB) treatment of K562 erythroleukemia cells increased their sensitivity to be killed by NK-92 cells with more than 10%, compared to untreated cells. A similar treatment of non-T, non-B acute lymphoblastic REH leukemia cells, known to be unsensitive to NK cell mediated cytotoxicity, did not have any impact at all. Visualization of the cross-linked ganglioside(M1) (GM(1)) using fluorescent labeled CTB, indicated accumulation of the fluorescence to one cap and a few smaller patches in both type of cells. Additional cross-linking using anti-CTB antibodies further accentuated capping and increased lysis in the case of K562 cells. Blocking experiments performed with anti-MICA/B, ULBP-2 and/or CD59 antibodies could not inhibit the increased sensitivity mediated by CTB.

机译：与未经处理的细胞相比，霍乱毒素B亚基（CTB）处理K562红白血病细胞的敏感性被NK-92细胞杀死的敏感性提高了10％以上。已知对NK细胞介导的细胞毒性不敏感的非T，非B急性淋巴细胞REH白血病细胞的类似治疗根本没有任何影响。使用荧光标记的CTB可视化交联的神经节苷脂（M1）（GM（1）），表明荧光在两种类型的细胞中积累到一个帽和一些较小的斑块。在使用K562细胞的情况下，使用抗CTB抗体进行的其他交联进一步加重了封端并增加了裂解。用抗MICA / B，ULBP-2和/或CD59抗体进行的阻断实验不能抑制CTB介导的敏感性增加。

著录项

来源
《Cellular immunology》 |2011年第1期|共4页
作者
Mrowczynska L; Bobrowska Hagerstrand M; Hagerstrand H; Lindqvist C;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词

相似文献

外文文献
中文文献
专利

1. Increased sensitivity of cholera toxin B treated K562 cells to natural killer cells. [J] . Mrowczynska L, Bobrowska Hagerstrand M, Hagerstrand H, Cellular immunology . 2011,第1期

机译：霍乱毒素B处理的K562细胞对自然杀伤细胞的敏感性增加。
2. Interactions between human natural killer (NK) lymphocytes and yeast cells: human NK cells do not kill Candida albicans, although C. albicans blocks NK lysis of K562 cells. [J] . S J Zunino, D Hudig Infection and immunity . 1988,第3期

机译：人类自然杀伤（NK）淋巴细胞与酵母细胞之间的相互作用：尽管白色念珠菌能阻止K562细胞的NK裂解，但人类NK细胞不会杀死白色念珠菌。
3. Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells. [J] . Yamagiwa S, Matsuda Y, Ichida T, Hepatology research: the official journal of the Japan Society of Hepatology . 2008,第7期

机译：慢性丙型肝炎对干扰素-α联合利巴韦林治疗的持续反应与肝内自然杀手和自然杀手T细胞的活力增加密切相关。
4. Cholera Toxin Subunit B-Modified Mesoporous Silica Nanoparticles as Vehicles for the Improved intracellular Delivery of Proteins [C] . William Walker, Juan L. Vivero-Escoto Society for Biomaterials annual meeting and exposition . 2015

机译：霍乱毒素亚基B修饰的介孔二氧化硅纳米粒子作为载体改善蛋白质的细胞内传递。
5. Cholera toxin subunit B and T cell receptor signaling pathways in differentially primed CD8+ T cells. [D] . Burillo-Kirch, Christine Amparo. 2003

机译：差异引发的CD8 + T细胞中的霍乱毒素亚基B和T细胞受体信号通路。
6. A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell K562 [O] . 1985

机译：人类自然杀伤细胞分化的模型。利用对自然杀伤敏感的肿瘤细胞K562体外激活Leu-11 +粒状淋巴细胞的研究
7. A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562 [O] . 1985

机译：人类自然杀伤细胞分化的模型。利用对自然杀伤敏感的肿瘤细胞K562体外激活Leu-11 +粒状淋巴细胞的研究
8. Immunoultrastructural Studies of Human NK (Natural Killer) Cells. 1. Ultracytochemistry and Comparison with T Cell Subsets [R] . Kang, Y. H., Carl, M., Grimley, P. M., 1987

机译：人NK（自然杀伤）细胞的免疫结构研究。 1.超微细胞化学与T细胞亚群的比较

Increased sensitivity of cholera toxin B treated K562 cells to natural killer cells.

摘要

著录项

相似文献

相关主题

期刊订阅