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首页> 外文期刊>Cellular immunology >Do CD4+ Foxp3+ Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation.
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Do CD4+ Foxp3+ Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation.

机译：CD4 + Foxp3 + Treg细胞是否与移植结果相关：对实体器官移植接受者的系统评价。

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Regulatory T cells (Tregs) are considered to be critical for the induction of transplant tolerance. Tregs counts were measured in blood, biopsy and urine sample after transplantation in many studies. Although not unanimous, some studies have suggested that Tregs is associated with better outcome and can also serve as an immune marker to predict the individual risk of rejection and identify tolerant patients. In this study, we systematically reviewed the correlation between Tregs and transplant outcomes, identifying if Tregs can predict transplant rejection and tolerance. A total of 22 articles were included and assessed, the results showed that Tregs in recipients are helpful to maintain a stable graft function, reduce acute/chronic rejection rate. And the Tregs in graft and urine, rather than in PBL, may have a better diagnostic value for transplant outcomes. However, since the low quality of included studies, results may be influenced by bias. More high quality studies with bigger sample size are still needed in future.
机译：调节性T细胞（Tregs）被认为对诱导移植耐受性至关重要。在许多研究中，在移植后的血液，活检和尿液样本中测量了Tregs计数。尽管不是一致的，但是一些研究表明，Treg与更好的预后相关，并且还可以作为免疫标记物来预测个体排斥的风险并确定耐受的患者。在这项研究中，我们系统地回顾了Treg与移植结果之间的相关性，确定Treg是否可以预测移植排斥和耐受性。总共纳入22篇文章并进行评估，结果表明，受体中的Tregs有助于维持稳定的移植物功能，降低急性/慢性排斥率。移植物和尿液中的Tregs，而不是PBLs，对于移植结果可能具有更好的诊断价值。但是，由于纳入研究的质量较差，结果可能会受到偏见的影响。将来仍然需要进行更多高质量的研究，并增加样本量。

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