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首页> 外文期刊>Cellular immunology >Early postnatal development of the immune system in piglets: The redistribution of T lymphocyte subsets
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Early postnatal development of the immune system in piglets: The redistribution of T lymphocyte subsets

机译：仔猪免疫系统的出生后早期发育：T淋巴细胞亚群的重新分布

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摘要

In this study, we have characterised postnatal changes in T lymphocyte subsets, especially gamma delta T lymphocytes, in blood, spleen and lymph nodes. Detection was carried out using two-colour flow cytometry and three-colour immunohistochemistry. During ontogeny, there was a significant increase in the total percentage of gamma delta T cells in the spleen and blood. In the lymph nodes, there were no age-dependent changes in the total percentage of gamma delta T cells, but the percentage of the gamma delta TCR(+)CD8(+) subpopulation significantly increased. The tissue distribution of gamma delta TCR(+)CD8(+) and gamma delta TCR(+)CD8(-) cells in the lymph nodes is random and not collocated with a particular area of the organ. Furthermore, postnatal development was characterised by an increasing frequency of CD8(+)CD3(+)CD4(-)gamma delta TCR-, which was compensated by a decreasing proportion of CD4(+) lymphocytes. Double positive CD4(+)CD8(+) lymphocytes were rare during the first month of life and a significant age-dependent increase of these cells was found in all. the compartments monitored. (C) 2007 Elsevier Inc. All rights reserved.
机译：在这项研究中，我们已经表征了血液，脾脏和淋巴结中T淋巴细胞亚群（尤其是伽马三角洲T淋巴细胞）的产后变化。使用两色流式细胞仪和三色免疫组织化学进行检测。在个体发育过程中，脾脏和血液中γ-δT细胞的总百分比显着增加。在淋巴结中，γ-δT细胞的总百分比没有年龄依赖性的变化，但γ-δTCR（+）CD8（+）亚群的百分比显着增加。淋巴结中的γ-δTCR（+）CD8（+）和γ-δTCR（+）CD8（-）细胞的组织分布是随机的，并且不与器官的特定区域并置。此外，产后发育的特征是CD8（+）CD3（+）CD4（-）γδTCR-的频率增加，而CD4（+）淋巴细胞的比例减少可以弥补这种情况。双阳性CD4（+）CD8（+）淋巴细胞在生命的头一个月中很少见，并且所有这些细胞的年龄均显着增加。监控的车厢。 （C）2007 Elsevier Inc.保留所有权利。

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