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首页> 外文期刊>Cellular immunology >Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates
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Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates

机译：非人类灵长类动物的造血细胞在组成型和SIV感染中诱导Siglecs表达的差异

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摘要

The expression of the Siglec family of molecules by hematopoietic cells from uninfected and SIV infected disease susceptible rhesus macaques (RM) and SIV infected disease resistant sooty mangabeys (SM) and for comparison humans was carried out. The predominant cell lineage in all three species expressing Siglec's was monocytes. The major finding by both a cross sectional and a prospective SIV infection study showed that, whereas monocytes from RM show marked increase in each Siglec constitutively expressed, monocytes from SM showed marked decreases in Siglec-1 expression. While monocytes from all three species constitutively expressed Siglec-3, human monocytes in addition expressed Siglec-5 and -9 and to a lower density 7, monocytes from RM expressed Siglec-7 and those from SM expressed Siglec-1. Monocytes from all three species, however, expressed mRNA for Siglec-1, -5, -7 and -9. The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed. (c) 2008 Elsevier Inc. All rights reserved.
机译：进行了未感染和SIV感染的易患恒河猴（RM）和SIV感染的抗病性黑豆猕猴（SM）的造血细胞表达Siglec分子家族的比较。在所有三个表达Siglec的物种中，主要的细胞谱系是单核细胞。横断面和前瞻性SIV感染研究的主要发现表明，虽然RM的单核细胞在组成型表达的每个Siglec中均显示显着增加，而SM的单核细胞却显示Siglec-1的表达显着下降。来自所有三个物种的单核细胞组成性表达Siglec-3，而人类单核细胞另外表达Siglec-5和-9，而密度较低的人单核细胞则表达Siglec-3，来自RM的单核细胞表达Siglec-7，来自SM的单核细胞表达Siglec-1。然而，来自所有三个物种的单核细胞表达Siglec-1，-5，-7和-9的mRNA。讨论了未能在蛋白质水平上检测到这些分子的原因以及SIV感染对Siglec表达的这种独特影响的机制。 （c）2008 Elsevier Inc.保留所有权利。

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