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首页> 外文期刊>Radiology >Toxoplasmosis and primary central nervous system lymphoma in HIV infection: diagnosis with MR spectroscopy.
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Toxoplasmosis and primary central nervous system lymphoma in HIV infection: diagnosis with MR spectroscopy.

机译：HIV感染中的弓形虫病和原发性中枢神经系统淋巴瘤：MR光谱诊断。

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PURPOSE: To differentiate intracranial lymphoma from Toxoplasma gondii lesions in patients infected with the human immunodeficiency virus, by means of localized spin-echo proton magnetic resonance (MR) spectroscopy. MATERIALS AND METHODS: Twenty-seven lesions were studied (18 T gondii lesions, nine lymphoma lesions) at 1.5 T. Spectra were acquired at an echo time of 135 msec from voxels centered on the lesions. Both visual analysis and spectral fitting were used to obtain metabolite ratios for choline (Cho), creatine (Cr), N-acetyl (NA), lactate, and lipids. RESULTS: Three spectral categories were seen. One had large lipid peaks with suppression of other metabolites. Another had an elevated Cho/Cr ratio with relatively diminished NA. The third had features of the other two. Examples of each spectrum type were acquired from both T gondii and lymphoma lesions. Neither method of analysis allowed differentiation between lesion types. MR spectroscopy showed an overlap of spectra. CONCLUSION: The authors conclude that toxoplasmosis and lymphoma cannot be differentiated with spin-echo proton MR spectroscopy at 135 msec.
机译：目的：通过局部自旋回波质子磁共振波谱技术来区分感染人类免疫缺陷病毒的患者的颅内淋巴瘤和弓形虫。材料与方法：研究了1.5 T下的27个病变（18 T刚地皮病变，9个淋巴瘤病变）。在135毫秒的回波时间内从位于病变中心的体素获取了光谱。目视分析和光谱拟合均用于获得胆碱（Cho），肌酸（Cr），N-乙酰（NA），乳酸和脂质的代谢物比率。结果：观察到三个光谱类别。其中一个具有较大的脂质峰，并具有其他代谢物的抑制作用。另一个具有较高的Cho / Cr比，同时NA相对降低。第三个具有其他两个特征。每种光谱类型的实例均从弓形虫和淋巴瘤病变中获得。两种分析方法均无法区分病变类型。 MR光谱显示光谱重叠。结论：作者得出结论，自旋回波质子磁共振波谱在135毫秒无法分辨弓形虫病和淋巴瘤。

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