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首页> 外文期刊>Cell and Tissue Research >The role of endothelial cell biology in endocarditis.
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The role of endothelial cell biology in endocarditis.

机译：内皮细胞生物学在心内膜炎中的作用。

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The treatment of endocarditis remains a challenge for physicians, even in times of modern antibiotic treatment. Depending on its cause, endocarditis can either be of infectious or non-infectious origin. Infective endocarditis is caused by bacterial (or fungal) pathogens, and the clinical course is critically dependent on the virulence factors of the specific microorganisms involved. Therefore, the clinical type of endocarditis can be divided into an acute and more aggressive form and a subacute form (endocarditis lenta). Much of our knowledge regarding the pathogenesis of infective endocarditis is based on studies of the virulence of Staphylococcus aureus, which has become the most frequent cause of infective endocarditis nowadays. However, independently of the underlying cause of endocarditis (infectious or noninfectious), the pathogenesis involves the damage and disturbance of endothelial function and the formation of associated vegetation endothelium in the pathogenesis of endocarditis. This review will thus give insights into current knowledge of the pathogenesis of endocarditis with a focus on the role of the endothelium.
机译：即使在现代抗生素治疗期间，心内膜炎的治疗对医生仍然是一个挑战。根据其原因，心内膜炎可以是传染源或非传染源。感染性心内膜炎是由细菌（或真菌）病原体引起的，临床过程严重取决于所涉及的特定微生物的毒力因子。因此，心内膜炎的临床类型可分为急性和更具侵略性的形式和亚急性形式（心内膜炎）。关于感染性心内膜炎的发病机理，我们的许多知识都是基于对金黄色葡萄球菌毒力的研究，这已成为当今感染性心内膜炎的最常见原因。然而，独立于心内膜炎的根本原因（感染性或非感染性），发病机制涉及心内膜炎的发病机制中内皮功能的损害和干扰以及相关的植物内皮的形成。因此，本综述将以内皮细胞的作用为重点，深入了解心内膜炎的发病机理。

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