Trichostatin A Modulates Expression of p21~(waf1/cip1), Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

Bodo Eickhoff; Stephan Ruller; Thomas Laue; Gotje Kohler; Christian Stahl; Max Schlaak; Jurgen van der Bosch

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Trichostatin A Modulates Expression of p21~(waf1/cip1), Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

机译：曲古抑素A调节人肺腺癌细胞p21〜（waf1 / cip1），Bcl-xL，ID1，ID2，ID3，CRAB2，GATA-2，hsp86和TFIID / TAFII31 mRNA的表达

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Lung adenocarcinoma cells treated for 16 h with trichostatin A(TSA), an inhibitor of histone deacetylases, and untreated cells were analyzed with respect to differential gene expression. Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21~(waf1/cip1), GATA-2, hsp86, ID1, ID2, and ID3 mRNA expression, which could be verified by Northern blotting. ID2 induction was further confirmed by Taqman realtime quantitative RT-PCR. The described alterations of gene expression due to TSA renders the lung adenocarcinoma cells susceptible to induction of apoptosis.

机译：用三联蛋白A（TSA）（一种组蛋白脱乙酰基酶抑制剂）处理了16小时的肺腺癌细胞，并对未处理的细胞进行了差异基因表达分析。 cDNA阵列的复杂杂交揭示了Bcl-xL，CRAB2和TFIID / TAFII31的阻遏以及p21〜（waf1 / cip1），GATA-2，hsp86，ID1，ID2和ID3 mRNA表达的诱导，这可以通过验证北方印迹。 Ta2man实时定量RT-PCR进一步证实了ID2的诱导。所述的由于TSA引起的基因表达改变使肺腺癌细胞易于诱导细胞凋亡。

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《Biological chemistry》 |2000年第2期|共6页
作者
Bodo Eickhoff; Stephan Ruller; Thomas Laue; Gotje Kohler; Christian Stahl; Max Schlaak; Jurgen van der Bosch;
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正文语种 eng
中图分类生物化学;
关键词
apoptosis; cDNA array; complex hybridization; histone deacetylase inhibitor; taqman;

机译：细胞凋亡;cDNA阵列;复杂杂交;组蛋白脱乙酰基酶抑制剂;taqman;

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Trichostatin A Modulates Expression of p21~(waf1/cip1), Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in Human Lung Adenocarcinoma Cells

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