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首页> 外文期刊>Radiology >IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model.
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IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model.

机译：IN-1233，ALK-5抑制剂：在大鼠尿道模型中裸金属支架放置后防止肉芽组织形成。

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PURPOSE: To evaluate the efficacy of an activin receptor-like kinase-5 inhibitor, IN-1233, for the prevention of tissue hyperplasia after bare stent placement in a rat urethral model. MATERIALS AND METHODS: Procedures were performed in accordance with the National Institutes of Health guidelines for humane handling of animals; approval of the committee of animal research was obtained. In 20 Sprague-Dawley male rats (weight range, 300-350 g), a self-expanding metallic bare stent was inserted in the urethra by using fluoroscopic guidance. One group of 10 rats (group A) was treated with IN-1233, the other group of 10 rats (group B) received no treatment. Retrograde urethrography was performed 4 and 8 weeks after stent placement. All rats were sacrificed at 8 weeks for histologic analysis. RESULTS: Stent placement was technically successful in all rats. The average stent diameter was significantly larger in group A compared with group B at follow-up retrograde urethrography performed 4 (P = .006) and 8 (P < .001) weeks after stent placement. At histologic analysis, the percentage of granulation tissue area (P < .001), thickness of submucosal fibrosis (P < .001), and number of epithelial layers (P < .001) were significantly decreased in group A compared with group B. Inflammatory cell infiltration (P < .001) was significantly increased in group A compared with group B. CONCLUSION: IN-1233 is effective for the prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model.
机译：目的：评估激活素受体样激酶5抑制剂IN-1233在裸露支架置入大鼠尿道模型后预防组织增生的功效。材料与方法：按照美国国家卫生研究院对动物进行人道处理的指导原则进行操作。获得了动物研究委员会的批准。在20只Sprague-Dawley雄性大鼠（体重范围300-350 g）中，使用荧光镜引导将自膨式金属裸支架插入尿道。一组10只大鼠（A组）用IN-1233治疗，另一组10只大鼠（B组）未接受治疗。支架置入后4和8周进行逆行尿道造影。在第8周处死所有大鼠以进行组织学分析。结果：技术上，所有大鼠均成功置入支架。在支架置入后第4周（P = .006）和第8周（P <.001）进行随访的逆行尿道造影，A组的平均支架直径明显大于B组。在组织学分析中，与B组相比，A组肉芽组织面积百分比（P <.001），粘膜下纤维化厚度（P <.001）和上皮层数（P <.001）显着降低。与B组相比，A组炎性细胞浸润（P <.001）显着增加。结论：IN-1233可有效预防裸露金属支架置入大鼠尿道模型后肉芽组织的形成。

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